Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China
Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China
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DOI：
10.2471/blt.06.034033
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发表时间：
2007-07-01
期刊：
影响因子：
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通讯作者：
Li, Yue-Sheng
中科院分区：
文献类型：
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作者：
Balen, Julie;Zhao, Zheng-Yuan;Li, Yue-Sheng
目的了解湖南省洞庭湖区日本血吸虫感染的流行、强度及相关发病率，估算湖南省洞庭湖区人群和水牛感染人数。共对湖南省47个村进行了人体血清学检查47144次，粪便检查7205次，临床检查和问卷调查3893次，水牛粪便检查874次。血清学检测采用酶联免疫吸附试验技术，人粪便标本检测采用Kato-Katz法。用毛虫孵化试验检测水牛和其他家畜粪便中的血吸虫感染情况，发现血吸虫血清感染率为11.9%(村级范围为1.3-34.9%)，粪便虫卵阳性率估计为1.9%(0-10.9%)。水牛感染率为9.5%(0~66.7%)。根据洞庭湖地区的整个人口推算，估计有73225人和13973头水牛被感染。最常见的症状是腹痛(6.2%)和便血(2.7%)。超过一半的接受临床检查的人报告至少接受过一次抗日本血吸虫治疗。结论自1995年进行的上一次全国PES以来，感染日本血吸虫的人数显著减少，部分原因是大规模的化疗活动。然而，水牛感染的数量接近稳定，这表明人类继续再次感染，这可能导致未来人类流行率的上升。
Objective To determine the prevalence and intensity of Schistosoma japonicum infection and associated morbidity, and to estimate the infected human and buffalo populations in the Dongting Lake region, Hunan province, China.Methods We used data from the third national schistosomiasis periodic epidemiological survey (PES) of 2004. These included 47 144 human serological and 7205 stool examinations, 3893 clinical examinations and questionnaire surveys, and 874 buffalo stool examinations, carried out in 47 villages in Hunan province. Serological examinations were performed using the enzyme linked immunosorbent assay technique and human stool samples were examined by the Kato-Katz method. Stools from buffaloes and other domestic animals were examined for schistosome infection by the miracidial hatching test.Findings Sero-prevalence was 11.9% (range: 1.3-34.9% at the village level), and the rate of egg-positive stools was estimated at 1.9% (0-10.9%) for the same population. The prevalence of infection among buffaloes was 9.5% (0-66.7%). Extrapolating to the entire population of the Dongting Lake region, an estimated 73 225 people and 13 973 buffaloes were infected. Most frequently reported symptoms were abdominal pain (6.2%) and bloody stools (2.7%). More than half of the clinically examined people reported having had at least one prior antischistosomal treatment.Conclusion There was a significant reduction in the number of humans infected with S. japonicum since the previous national PES carried out in 1995, partially explained by large-scale chemotherapy campaigns. However, a near-stable number of buffalo infections suggest continuing human re-infection, which may lead to future increases in human prevalence.