Abnormal FHIT transcripts in human breast carcinomas: a clinicopathological and epidemiological analysis of 61 Japanese cases.
Abnormal FHIT transcripts in human breast carcinomas: a clinicopathological and epidemiological analysis of 61 Japanese cases.
复制标题
人类乳腺癌中 FHIT 转录物异常：61 例日本病例的临床病理学和流行病学分析。
作者：
S. Hayashi;K. Tanimoto;Kyoko Hajiro;E. Tsuchiya;M. Kurosumi;Y. Higashi;K. Imai;K. Suga;K. Nakachi
在包括乳腺癌在内的各种人类癌症中发现了3号染色体短臂的缺失。最近，脆性组氨酸三联体（fragile histidine triad，FHIT）基因被鉴定为3p14.2的候选抑癌基因。我们检查了61例日本原发性乳腺癌标本中FHIT基因的异常转录本，发现其中23例（38%）表现出异常，其中约一半被归类为两种类型的异常转录本。对这些异常转录本的序列分析揭示了外显子5-7（I型）和外显子5-8（II型）的缺失。临床病理学和流行病学分析显示，FHIT基因异常表达与患者年龄、肿瘤淋巴结转移类型、肿瘤大小、雌激素受体和孕激素受体状态、局部转移、乳腺癌家族史以及吸烟、饮酒等生活方式因素无关。另一方面，我们发现I型和II型转录本异常与双侧乳腺癌的发病率有关，分娩频率降低也与FHIT异常有关。
Deletions in the short arm of chromosome 3 have been found in various human cancers, including breast cancer. Recently, the FHIT (fragile histidine triad) gene was identified at 3p14.2 as a candidate tumor suppressor gene. We examined the abnormal transcripts of the FHIT gene in 61 Japanese primary breast cancer specimens and found that 23 (38%) of them exhibited abnormalities, about half of which were categorized into two types of aberrant transcripts. Sequence analysis of these aberrant transcripts revealed the absence of exons 5-7 (type I) and exons 5-8 (type II). Clinicopathological and epidemiological analysis of patients showed that the abnormal FHIT transcripts were not associated with age, tumor-node-metastasis classification, tumor size, estrogen receptor and progesterone receptor status, local metastasis, family history of breast cancer, or lifestyle factors of patients, including cigarette smoking and alcohol consumption. On the other hand, we found that the abnormal transcripts of type I and type II were associated with the incidence of bilateral breast cancer and that decreased frequency of childbirth was also associated with FHIT abnormalities.
影响因子：
11.2
作者：
Ling Chen;Kouji Matsumura;Guoren Deng;W. Kurisu;B. Ljung;M. Lerman;Frederick M. Waidman;Helene S. Smith
通讯作者：
Ling Chen;Kouji Matsumura;Guoren Deng;W. Kurisu;B. Ljung;M. Lerman;Frederick M. Waidman;Helene S. Smith
爱荷华州妇女健康研究中的黄体酮和雌激素受体与乳腺肿瘤：乳腺癌有多少种？
DOI：
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发表时间：
1995
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Potter,JD;Cerhan,JR;Sellers,TA;McGovern,PG;Drinkard,C;Kushi,LR;Folsom,AR
通讯作者：
Folsom,AR