CCAAT-ENHANCER BINDING-PROTEIN - A COMPONENT OF A DIFFERENTIATION SWITCH
CCAAT-ENHANCER BINDING-PROTEIN - A COMPONENT OF A DIFFERENTIATION SWITCH
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DOI：
10.1126/science.1987644
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发表时间：
1991-01-18
期刊：
影响因子：
56.9
通讯作者：
MCKNIGHT, SL
中科院分区：
文献类型：
--
作者：
UMEK, RM;FRIEDMAN, AD;MCKNIGHT, SL
The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase where-in proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.
