MORPHOGENESIS OF PALATE IN NORMAL HUMAN EMBRYOS WITH SPECIAL EMPHASIS ON MECHANISMS INVOLVED
MORPHOGENESIS OF PALATE IN NORMAL HUMAN EMBRYOS WITH SPECIAL EMPHASIS ON MECHANISMS INVOLVED
复制标题
DOI：
10.1002/aja.1001200112
复制
发表时间：
1967-01-01
影响因子：
--
通讯作者：
FAIST, K
中科院分区：
文献类型：
--
作者：
BURDI, AR;FAIST, K
本研究的目的是重新评估融合作为正常人类胚胎软硬腭闭合机制的经典描述。软腭的发育是不是像硬腭骨那样，是通过陆架的后部延续、上皮的分层和解体以及间充质细胞的融合来发展的？或者软腭的发育是由于融合硬腭后缘上皮下间质生长中心的增殖和迁移，从而使分隔软腭部两个原始突起的早期沟槽逐渐被沟槽底部的间充质融合所消除？在腭部闭合之前、期间和之后(7-12周，18-75 mm C-R长度)对人类胚胎的观察表明，从初级腭部开始的腭部闭合前后梯度和仅在硬腭区发现的上皮融合残留物。这些观察结果表明，软腭的发育是由间充质融合的上皮移位而不是整个次级腭突的上皮融合所致。
The aim of this study was to re-evaluate the classical description of fusion as the closure mechanism of both the hard and soft palates in normal human embryos. Does the soft palate develop by a posterior continuation of shelf apposition, epithelial lamination and disintegration, and by mesenchymal cell fusion as described for the hard palate? Or does the soft palate develop by proliferation and migration of sub-epithelial mesenchymal growth centers at the posterior edge of the fused hard palate so that the early furrow which separates the two primordial processes of the soft palate is progressively obliterated by mesenchymal merging at the furrow base ? Observations of human embryos prior to, during, and after palatal closure (7-12 wks, 18-75 mm C-R length) indicated an anteroposterior gradient of palatal closure beginning at the primary palate and epithelial fusion remnants found only in the hard palate regions. These observations suggest that the soft palate develops by a displacement of epithelium by mesenchymal merging rather than by epithelial fusion of the entire secondary palatine processes.