Solubility Measurement and Stability Study of Sodium Cefuroxime
Solubility Measurement and Stability Study of Sodium Cefuroxime
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DOI：
10.1021/je400938a
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发表时间：
2014-02
影响因子：
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通讯作者：
Wen J. Liu;Cai Y. Ma;Shengxiang Feng;X. Wang
中科院分区：
文献类型：
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作者：
Wen J. Liu;Cai Y. Ma;Shengxiang Feng;X. Wang
自从头孢呋辛钠作为一种有价值的抗生素被发明以来，它的稳定性一直是一个主要问题。本研究采用在线衰减全反射-傅里叶变换红外光谱技术监测头孢呋辛钠抗溶剂重结晶实验中过饱和度的变化并优化溶剂流速。测量了头孢呋辛钠在不同温度、pH值和溶剂下的溶解度，并在模型中进行了关联。考察了反溶剂（79.1%乙醇）流速对产物结晶度的影响，并用x射线衍射、扫描电镜和稳定性试验对产物进行了分析。结果表明，适宜的平均粒径、均匀的粒径分布和良好的结晶状态可以提高头孢呋辛钠的稳定性。在此操作条件下，该再结晶过程的最佳抗溶剂流速为2 mL·min-1。
The stability of sodium cefuroxime has been a major concern since it was invented as a valuable antibiotic. In this study, online attenuated total reflection-fourier transform infrared spectroscopy was applied to monitor the change in supersaturation and optimize the solvent flow rate in antisolvent recrystallization experiments of sodium cefuroxime. The solubility of sodium cefuroxime under various temperatures T, pH values, and solvents was measured and correlated in models. The effect of the antisolvent (79.1 % ethanol) flow rate on crystallinity was examined, and the products were analyzed by X-ray diffraction, scanning electron microscopy, and stability test. The results showed that appropriate mean particle size, uniform particle size distribution, and good crystalline state could improve the stability of sodium cefuroxime. The optimum antisolvent flow rate for this recrystallization process under these operating conditions was found to be 2 mL·min–1.