Role of the paraventricular nucleus microenvironment in stress integration
Role of the paraventricular nucleus microenvironment in stress integration
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DOI：
10.1046/j.1460-9568.2002.02133.x
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发表时间：
2002-08-01
影响因子：
3.4
通讯作者：
Tasker, JG
中科院分区：
文献类型：
--
作者：
Herman, JP;Cullinan, WE;Tasker, JG
下丘脑室旁核是下丘脑-垂体-肾上腺皮质糖皮质激素释放的主要控制者。在执行这一功能时，室旁核将来自外部和内部的各种信息汇总成一个净分泌信号，传递给肾上腺皮质。在这篇综述中，我们将概述控制垂体营养神经元激活和抑制的神经元回路机制，重点介绍我们对调节室旁细胞活动的非突触机制的最新进展，包括树突神经肽释放、直接类固醇反馈、细胞因子级联和气体神经传递，并说明垂体营养的能力。神经垂体和自主神经前室旁效应通路共同控制糖皮质激素释放。目前的知识表明室旁核是一个动态的实体，能够整合不同种类的信号来控制肾上腺皮质的激活。
The hypothalamic paraventricular nucleus is the primary controller of hypothalamo-pituitary-adrenocortical glucocorticoid release. In performing this function, the paraventricular nucleus summates a variety of information from both external and internal sources into a net secretory signal to the adrenal cortex. In this review, we will provide an overview of neuronal circuit mechanisms governing activation and inhibition of hypophysiotrophic neurons, highlight recent developments in our understanding of nonsynaptic mechanisms regulating paraventricular cellular activity, including dendritic neuropeptide release, direct steroid feedback, cytokine cascades and gaseous neurotransmission, and illustrate the capacity for hypophysiotrophic, neurohypophysial and preautonomic paraventricular effector pathways to work together in control of glucocorticoid release. The current state of knowledge reveals the paraventricular nucleus to be a dynamic entity, capable of integrating diverse classes of signals into control of adrenocortical activation.