Pd-Catalyzed α-Arylation of Nitriles and Esters and γ-Arylation of Unsaturated Nitriles with TMPZnCl•LiCl
Pd-Catalyzed α-Arylation of Nitriles and Esters and γ-Arylation of Unsaturated Nitriles with TMPZnCl•LiCl
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DOI：
10.1021/ol200194y
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发表时间：
2011-04-01
期刊：
影响因子：
5.2
通讯作者：
Knocher, Paul
中科院分区：
文献类型：
--
作者：
Duez, Stephanie;Bernhardt, Sebastian;Knocher, Paul
使用TMPZnCl中心点“LiCl作为动力学高活性碱，腈和酯在温和条件下进行Pd催化的α-芳基化反应。值得注意的是，在α、β或β、γ-不饱和腈的情况下，观察到区域选择性γ-芳基化或γ-烯基化。
Using TMPZnCl center dot"LiCl as a kinetically highly active base, nitriles and esters undergo a Pd-catalyzed alpha-arylation under mild conditions. Remarkably, in the case of alpha,beta or beta,gamma-unsaturated nitriles, a regioselective gamma-arylation or a gamma-alkenylation is observed.