ELECTROCHEMICAL PERFORMANCE, BIOCOMPATIBILITY, AND ADHESION OF NEW POLYMER MATRICES FOR SOLID-STATE ION SENSORS
ELECTROCHEMICAL PERFORMANCE, BIOCOMPATIBILITY, AND ADHESION OF NEW POLYMER MATRICES FOR SOLID-STATE ION SENSORS
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DOI：
10.1021/ac00017a003
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发表时间：
1991-09-01
影响因子：
7.4
通讯作者：
BROWN, RB
中科院分区：
文献类型：
--
作者：
CHA, GS;LIU, D;BROWN, RB
铵和钾离子选择性膜与聚氯乙烯/羟基化聚氯乙烯，聚氨酯/羟基化聚氯乙烯，和湿固化的硅橡胶矩阵制定了研究，努力延长固态离子传感器的寿命，通过改善膜的粘附力。 PVC/羟基化PVC和聚氨酯/羟基化PVC膜在斜率、检测限和选择性方面表现出与常规PVC膜相当的电化学性能。 基于聚氨酯和硅橡胶的膜与氮化硅的粘附性优于PVC或羟基化PVC基质。 硅烷化试剂（四氯化硅）的加入显著改善了聚氨酯基质的粘附性。 在膜基质中使用四氯化硅还增强了固态传感器的离子选择性聚合物基质膜和银环氧树脂内参比电极之间的界面电位的电化学稳定性。 通过放射性示踪剂蛋白质吸附研究和全血凝血时间测量检查聚合物基质的生物相容性。 与PVC或羟基化PVC基质相比，聚氨酯和硅橡胶基膜的总体非特异性蛋白质吸附较少。
Ammonium and potassium ion-selective membranes formulated with PVC/hydroxylated PVC, polyurethane/hydroxylated PVC, and moisture-curable silicone rubber matrices are studied in an effort to extend the lifetime of solid-state ion sensors through improved membrane adhesion. The PVC/hydroxylated PVC and polyurethane/hydroxylated PVC membranes exhibit electrochemical performance equivalent to that of conventional PVC membranes in terms of slope, detection limit, and selectivity. The polyurethane- and silicone-rubber-based membranes have better adhesion to silicon nitride than do PVC or hydroxylated PVC matrices. Incorporating a silanizing reagent (silicon tetrachloride) significantly improves the adhesion of the polyurethane matrix. The use of silicon tetrachloride in membrane matrices also enhances the electrochemical stability of the interfacial potential between ion-selective polymer-matrix membranes and silver epoxy inner reference electrodes of solid-state sensors. The bio-compatibility of the polymer matrices is examined via radio-tracer protein adsorption studies and whole blood clotting time measurements. The polyurethane- and silicone-rubber-based membranes exhibit less overall nonspecific protein adsorption than the PVC or hydroxylated PVC matrices.