Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection.
Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection.
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DOI：
10.2147/idr.s265718
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发表时间：
2020
影响因子：
3.9
通讯作者：
Chen SY
中科院分区：
文献类型：
--
作者：
Gao YL;Du Y;Zhang C;Cheng C;Yang HY;Jin YF;Duan GC;Chen SY
肾素-血管紧张素系统（RAS）是电解质稳态和血压最重要的调节系统，通过血管紧张素转换酶（ACE）/血管紧张素II（Ang II）/Ang II 1型（AT1）受体轴和血管紧张素转换酶2（ACE2）/血管紧张素（1-7）/MAS受体轴发挥作用。 RAS功能障碍与急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）的发生、发展有关，并导致严重的预后甚至死亡。 ALI/ARDS 可由多种途径诱发，其中之一是病毒感染，如 SARS-CoV、SARS-CoV-2、H5N1、H7N9 和 EV71。本文综述了RAS功能障碍影响病毒感染引起的ALI/ARDs的具体机制。 SARS-CoV 和 SARS-CoV-2 通过与 ACE2 结合进入宿主细胞。 H5N1和H7N9禽流感病毒降低体内ACE2水平，EV71增加Ang II浓度。血管紧张素转换酶抑制剂和血管紧张素AT1受体阻滞剂治疗可以缓解ALI/ARDS症状。本综述为病毒感染引起的肺损伤的治疗提供建议。
The renin-angiotensin system (RAS) is the most important regulatory system of electrolyte homeostasis and blood pressure and acts through angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 (AT1) receptor axis and angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7)/MAS receptor axis. RAS dysfunction is related to the occurrence and development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) and causes a serious prognosis and even death. ALI/ARDS can be induced by various ways, one of which is viral infections, such as SARS-CoV, SARS-CoV-2, H5N1, H7N9, and EV71. This article reviews the specific mechanism on how RAS dysfunction affects ALI/ARDs caused by viral infections. SARS-CoV and SARS-CoV-2 enter the host cells by binding with ACE2. H5N1 and H7N9 avian influenza viruses reduce the ACE2 level in the body, and EV71 increases Ang II concentration. Treatment with angiotensin-converting enzyme inhibitor and angiotensin AT1 receptor blocker can alleviate ALI/ARDS symptoms. This review provides suggestions for the treatment of lung injury caused by viral infections.