Evaluation of Leukocyte Surface Antigens in Patients with Multiple Sclerosis
Evaluation of Leukocyte Surface Antigens in Patients with Multiple Sclerosis
复制标题
多发性硬化症患者白细胞表面抗原的评估
DOI：
10.1111/j.1749-6632.1984.tb14797.x
复制
发表时间：
1984
影响因子：
5.2
通讯作者：
E. Mingioli
中科院分区：
文献类型：
--
作者：
D. McFarlin;E. Mingioli
虽然多发性硬化症（MS）的病因和发病机制尚不清楚，但长期以来一直认为异常的免疫功能可能起作用。近年来，抑制性T淋巴细胞在疾病中可能减少的概念受到了相当大的重视。在急性发作期间，已经描述了减少的Con A诱导的抑制细胞活性2和减少的T γ细胞。干扰素的产生受损。此外，一些研究人员观察到自然杀伤细胞的异常：但这一领域有些争议。6在开发出识别不同T淋巴细胞亚群的单克隆抗体之后，据报道，在MS急性发作期间，患者中由OKT 5抗血清定义的亚群减少。这被认为与MS中抑制细胞缺乏的概念一致，因为抑制同种异体混合淋巴细胞反应的Con A诱导的T细胞群显示为OKTS阳性。Bach等人也报道了减少的OKT 5细胞。随后引入OKT 8抗血清作为由OKT 5定义的同一组淋巴细胞的标记。利用该试剂，豪瑟等人”提供了淋巴细胞亚群变化与疾病活动相关的证据。然而，最近其他人”未能发现MS急性发作期间淋巴细胞表型的变化。在过去的三年里，神经免疫学分支对正在研究的患者进行了淋巴细胞表型检查。为了解释在患者中的发现，相当大的努力已经投入到正常个体的淋巴细胞的研究。本报告的目的是描述我们的研究结果，以正常人和MS患者的日期。
Although the etiology and pathogenesis of multiple sclerosis (MS) are unknown, it has long been believed that aberrant immune function may play a role.’ Within recent years the concept that suppressor T lymphocytes may be reduced in the disease has received considerable emphasis. During acute attacks reduced Con A-induced suppressor cell activity2 and reduced T gamma cells’ have been described. Impaired production of interferon has been In addition, some investigators have observed abnormalities of the natural killer cells: but this area is somewhat controversial.6 Subsequent to the development of monoclonal antibodies which recognize different subsets of T lymphocytes’ it was reported that the subset defined by the OKT5 antiserum was reduced in patients during acute episodes of MS.’ This was believed to be consistent with the notion of deficiency of suppressor cells in MS because the population of Con A-induced T cells which suppress the allogeneic mixed lymphocyte reaction’ was shown to be OKTS positive. Reduced OKT5 cells were also reported by Bach et al.’*; subsequently, the OKT8 antiserum was introduced as a marker for the same set of lymphocytes defined by OKT5. With this reagent, Hauser et al.” provided evidence that variation in lymphocyte subsets correlated with disease activity. However, recently others” have failed to find changes in lymphocyte phenotypes during acute episodes of MS. For the past three years lymphocyte phenotypes have been examined in patients being investigated by the Neuroimmunology Branch. In order to interpret the findings in patients, considerable effort has been devoted to the study of lymphocytes in normal individuals. The purpose of this report is to describe our findings to date in both normals and MS patients.
DOI：
10.1073/pnas.79.14.4395
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MEUER, SC;SCHLOSSMAN, SF;REINHERZ, EL
通讯作者：
REINHERZ, EL