Antiaging, longevity and calorie restriction
Antiaging, longevity and calorie restriction
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DOI：
10.1097/mco.0b013e3283331384
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
AlKaade, Saad
中科院分区：
文献类型：
--
作者：
Morley, John E.;Chahla, Elie;AlKaade, Saad
综述目的热量限制在人类中的作用是有争议的。最近，猴子和人类的新数据为卡路里限制在长寿中的潜在作用提供了新的见解。一项对恒河猴的研究表明，与衰老相关的死亡率降低。许多对照研究表明，在6-12个月的人类研究中，有各种有益的影响。对人类的主要负面影响是肌肉质量、肌肉力量和骨骼的损失。摘要啮齿类动物的饮食限制在老年啮齿类动物中没有显示出有效。60岁以上人群体重减轻与死亡率增加、髋部骨折和住院率增加有关。老年人的卡路里限制应该被认为是实验性的和潜在的危险。目前看来，锻炼对老年人来说是一种较好的治疗方法。
Purpose of reviewThe role of calorie restriction in humans is controversial. Recently, new data in monkeys and humans have provided new insights into the potential role of calorie restriction in longevity.Recent findingsA study in rhesus monkeys showed a reduction in aging-associated mortality. A number of controlled studies have suggested a variety of beneficial effects during studies of 6-12 months in humans. Major negative effects in humans were loss of muscle mass, muscle strength and loss of bone.SummaryDietary restriction in rodents has not been shown to be effective when started in older rodents. Weight loss in humans over 60 years of age is associated with increased mortality, hip fracture and increased institutionalization. Calorie restriction in older persons should be considered experimental and potentially dangerous. Exercise at present appears to be a preferable treatment for older persons.