Physiology of Bone
Physiology of Bone
复制标题
DOI：
10.1159/000223687
复制
发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Grabowski, Peter
中科院分区：
文献类型：
--
作者：
Grabowski, Peter
骨骼具有三个主要的生理功能。它的机械性质为运动提供支持并为脆弱的内脏器官提供保护，它形成体内钙和磷酸盐的储存库，并为骨髓和造血细胞的发育提供环境。在过去的半个世纪里，被动组织对激素和饮食影响做出反应的传统观点已经转变为对机械需求作出反应的动态适应性组织。本章汇集了骨生理学和分子细胞生物学的一些最新进展，并讨论了骨骼对负荷的功能适应在增强儿童和青少年时期骨骼强度方面的潜在应用。版权所有 (C) 2009 S. Karger AG，巴塞尔
Bone serves three main physiological functions. Its mechanical nature provides support for locomotion and offers protection to vulnerable internal organs, it forms a reservoir for storage of calcium and phosphate in the body, and it provides an environment for bone marrow and for the development of haematopoietic cells. The traditional view of a passive tissue responding to hormonal and dietary influences has changed over the past half century to one of a dynamic adaptive tissue responding to mechanical demands. This chapter gathers together some recent advances in bone physiology and molecular cell biology and discusses the potential application of the bone's functional adaptation to loading in enhancing bone strength during childhood and adolescence. Copyright (C) 2009 S. Karger AG, Basel