Sulindac suppresses tumorigenesis in the Min mouse
Sulindac suppresses tumorigenesis in the Min mouse
复制标题
DOI：
10.1093/carcin/17.8.1757
复制
发表时间：
1996-08-01
期刊：
影响因子：
4.7
通讯作者：
Kinzler, KW
中科院分区：
文献类型：
--
作者：
BeazerBarclay, Y;Levy, DB;Kinzler, KW
Min小鼠为遗传和散发形式的人类结直肠肿瘤发生提供了遗传定义的模型。为了测试该模型用于评价和优化化学预防剂的适用性，我们检查了舒林酸对Min小鼠肿瘤发生的影响，因为该化合物可以抑制人类家族性腺瘤性息肉病患者的结直肠肿瘤发生。在Min小鼠的饮用水（84 mg/l）或饮食（167和334 p. p.m.）中用舒林酸处理Min小鼠中舒林酸活性的保存为探索舒林酸抑制机制以及测试其他潜在的化学预防剂提供了机会。
The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sulindac on tumorigenesis in Min mice as this compound can inhibit colorectal tumorigenesis in human familial adenomatous polyposis patients. Treatment of Min mice with sulindac in their drinking water (84 mg/l) or diet (167 and 334 p.p.m.) resulted in a significantly decreased average tumor load, The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents.