Immunohistological study on collagenous proteins of benign and malignant human cartilaginous tumours of bone
Immunohistological study on collagenous proteins of benign and malignant human cartilaginous tumours of bone
复制标题
人良恶性骨软骨肿瘤胶原蛋白的免疫组织学研究
作者：
Y. Ueda;Y. Oda;H. Tsuchiya;K. Tomita;I. Nakanishi
本文研究了I、II、III、V、VI型胶原在人骨的良、恶性软骨肿瘤中的免疫组织学分布及其侵袭性。内生性软骨瘤的基质由II型胶原弥漫分布，VI型主要定位于细胞周围。未发现I型、III型和V型胶原。这些发现类似于正常透明软骨中胶原蛋白的分布，在正常透明软骨中，每个小叶都一致地被I型和V型胶原所包围。在1级软骨肉瘤中，基质的主要胶原成分也是II型和VI型胶原。II型有时见于肿瘤细胞的胞浆内，而VI型往往失去区域定位。此外，I型胶原持续存在，部分病例为V型胶原。在2级软骨肉瘤中，II型胶原不仅存在于基质中，有时也存在于肿瘤细胞的胞浆中。VI型分布于细胞间区。其他胶原蛋白如I、III和V型也存在于基质中。在3级软骨肉瘤中，II型胶原主要定位于肿瘤细胞的胞浆和邻近基质中。VI型细胞明显减少，细胞周围分布完全丧失，而I型、III型和V型在基质中持续存在。胶原蛋白类型分布的这些变化与肿瘤的侵袭性很好地相关。这些发现表明，软骨肿瘤中不同类型的胶原蛋白的分布反映了肿瘤细胞的不成熟，是反映其侵袭性的有用指标。
The immunohistological distribution of collagen types I, II, III, V and VI in human benign and malignant cartilaginous tumours of bone was examined with regard to their aggressiveness. The matrix of enchondromas consisted of type II collagen distributed diffusely, and type VI predominantly localized in the immediate surroundings of the cells. Types I, III and V collagen were not found. These findings were similar to the distribution of collagenous proteins in normal hyaline cartilage where each lobule was consistently rimmed by types I and V collagen. In grade 1 chondrosarcomas, the main collagenous components of matrix were also types II and VI collagen. Type II was sometimes found in the cytoplasm of tumour cells and type VI tended to lose territorial localization. In addition, type I collagen was demonstrated consistently and type V in some cases. In grade 2 chondrosarcomas, type II collagen was demonstrated not only in the matrix but occasionally in the cytoplasm of tumour cells. Type VI was dispersed in the intercellular areas. The other collagenous proteins such as types I, III and V were also present in the matrix. In grade 3 chondrosarcomas, type II collagen was localized predominantly in the cytoplasm of tumour cells and in the adjacent matrix. Type VI was markedly decreased with complete loss of pericellular distribution, whereas types I, III and V were constantly present in the matrix. Those alterations in the distribution of collagen types correlated well with the aggressive behaviour of the tumours. The findings suggest that distribution of different collagen types in cartilaginous tumours reflects the immaturity of the tumour cells and is a useful indicator of their aggressiveness.
影响因子：
4.2
作者：
Eriksson Ai;A. Schiller;H. Mankin
通讯作者：
Eriksson Ai;A. Schiller;H. Mankin