MATHEMATICAL-MODEL FOR STUDYING GENETIC-VARIATION IN TERMS OF RESTRICTION ENDONUCLEASES
MATHEMATICAL-MODEL FOR STUDYING GENETIC-VARIATION IN TERMS OF RESTRICTION ENDONUCLEASES
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DOI：
10.1073/pnas.76.10.5269
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
LI, WH
中科院分区：
文献类型：
--
作者：
NEI, M;LI, WH
建立了线粒体DNA限制性内切位点进化变化的数学模型。在此模型的基础上，提出了估算两个种群或物种之间核苷酸取代数的公式。为了在核苷酸水平上表达群体的多态性程度，提出了一种称为核苷酸多样性的测量方法。
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between 2 populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called nucleotide diversity is proposed.