Diet-induced alterations of hGH secretion in man.
Diet-induced alterations of hGH secretion in man.
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饮食引起的人类 hGH 分泌的改变。
DOI：
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发表时间：
1976
影响因子：
5.8
通讯作者：
C. Burton
中科院分区：
文献类型：
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作者：
T. Merimee;A. Pulkkinen;C. Burton
研究旨在确定饮食成分的变化是否会改变人类生长激素的分泌。八名男性和七名女性接受了为期 10-12 天的实验饮食。每个实验饮食之前都有五天的对照饮食。在男性中研究的实验饮食为：a) 2300 卡路里，80% 碳水化合物（8 名男性）； b) 2300 卡路里，75% 高脂肪（7 名男性）； c) 2300卡路里，70%高蛋白（5名男性）； d) 3600 卡路里，“对照”（40% 碳水化合物、40% 脂肪、20% 蛋白质）（5 名男性）； e) 3600 卡路里，80% 高碳水化合物（5 名男性）。控制饮食和高碳水化合物（5 名男性）。在女性中研究了对照饮食和 2300 卡路里水平的高碳水化合物饮食。每项饮食研究均以 72 小时禁食结束。在每个对照期后、每个研究的第八、第九或第十天以及每次禁食的最后一天，每小时收集一次血清样本，持续 24 小时。 2300 卡路里水平的高碳水化合物饮食导致 8 名男性中每人血清中生长激素值显着下降（显着性符号检验，P 小于 0.01）。平均数字同样显着下降。高脂肪和高蛋白的等热量饮食不会改变血清中生长激素的浓度。与对照饮食成分相似的高热量饮食对男性生长激素的分泌没有影响；然而，高热量水平的高碳水化合物饮食再次降低了血浆中的生长激素值。在 72 小时禁食的第三天，男性血清中的生长激素值增加了 287%，从平均对照血清浓度 4.4 +/- 0.8 ng/ml 增加到 11.9 +/- 5.0 ng/ml（P 小于 0.01）。与男性不同，女性在高碳水化合物饮食后 24 小时内血清中生长激素浓度没有显着下降，并且饥饿后的增加显着低于男性，仅在通过配对分析评估时才具有显着性。男性输注精氨酸后血清中的生长激素值遵循类似的模式，即在高碳水化合物后下降，但不受其他饮食的影响；高碳水化合物饮食并没有改变女性生长激素对精氨酸的反应。
Studies were designed to determine whether variations in diet composition could modify the secretion of human growth hormone. Eight men and seven women ingested experimental diets for 10-12 days. Each experimental diet was preceded by a control diet for five days. Experimental diets studied in men were a) 2300 calorie, 80% carbohydrate (8 men); b) 2300 calorie, 75% high-fat (7 men); c) 2300 calorie, 70% high-protein (5 men); d) 3600 calorie, "control" (40% carbohydrate, 40% fat, 20% protein) (5 men); and e) 3600 calorie, 80% high-carbohydrate (5 men). A control diet and a high-carbohydrate (5 men). A control diet and a high-carbohydrate diet at the 2300 calorie level were studied in women. Each diet study was terminated by a 72 hour fast. Serum samples were collected hourly for 24 hours after each control period, on the eigth, ninth, or tenth day of each study, and during the final day of each fast. High-carbohydrate diets at the 2300 calorie level caused a significant decrease of growth hormone values in serum in each of eight men (sign test of significance, P less than .01). The mean figures were likewise significantly decreased. Isocaloric diets of high fat and high protein did not alter growth hormone concentrations in serum. A high-caloric diet similar to the control diet in composition was without effect on growth hormone secretion in men; however, a high-carbohydrate diet at the higher caloric level again depressed growth hormone values in plasma. On the third day of a 72 hour fast, growth hormone values in serum increased 287% in men, from a mean control serum concentration of 4.4 +/- 0.8 ng/ml to 11.9 +/- 5.0 ng/ml (P less than .01). Women, unlike men, had no significant decrease in growth hormone concentrations in serum over a 24 hour period after the high-carbohydrate diet, and the increase after starvation was significantly less than that in men, achieving significance only when evaluated by paired analysis. Growth hormone values in serum after the infusion of arginine followed a similar pattern, i.e., decreased after high carbohydrate but unaffected by other diets in men; high carbohydrate diets did not alter the growth hormone response of women to arginine.