Late toxicity following conventional radiotherapy for prostate cancer: analysis of the EORTC trial 22863
Late toxicity following conventional radiotherapy for prostate cancer: analysis of the EORTC trial 22863
复制标题
DOI：
10.1016/j.ejca.2003.12.027
复制
发表时间：
2004-07-01
影响因子：
8.4
通讯作者：
Bolla, M
中科院分区：
文献类型：
--
作者：
Ataman, F;Zurlo, A;Bolla, M
欧洲癌症研究与治疗组织 (EORTC) 试验 22863 分析了晚期毒性和其他严重不良事件 (SAE)。该研究评估了辅助内分泌治疗对于接受放疗的局部晚期前列腺癌的价值。从 1987 年到 1995 年，415 名患者被随机分组。有 377 名患者 (91%) 的长期毒性信息。中位年龄为 70 岁（范围 50-80 岁）。晚期毒性的中位随访时间为 42 个月（范围 3-136 个月）。根据修改后的放射治疗和肿瘤学组（RTOG）量表对毒性进行分级。还评估了其他未归类为严重治疗毒性但仍危及生命的晚期 SAE。 2级毒性72例，3级毒性10例，4级毒性4例。有 20 名患有其他晚期 SAE 的患者，根据与治疗的关系进行分组；可能相关 (n = 1)、不相关 (n = 7) 和不可评估 (n = 12)。尽管发生了 4 例治疗相关死亡 (1%)，但 3 级或 4 级晚期并发症低于 5%。 (C) 2004 Elsevier Ltd. 保留所有权利。
Late toxicity and other serious adverse events (SAE) were analysed in the European Organisation for Research and Treatment of Cancer (EORTC) trial 22863. The study evaluated the value of adjuvant endocrine treatment for locally advanced prostate cancer treated with radiotherapy. From 1987 to 1995, 415 patients were randomised. There was long-term toxicity information for 377 patients (91%). Median age was 70 years (range 50-80 years). Median follow-up for late toxicity was 42 months (range 3-136 months). Toxicity was graded according to a modified Radiotherapy and Oncology Group (RTOG) scale. Other late SAE, that was not classified as severe treatment toxicity, but were still life-threatening, were also assessed. There were 72 patients with grade 2, 10 patients with grade 3 and 4 patients with grade 4 toxicity. There were 20 patients with other late SAE, who were grouped according to their relationship to treatment; likely related (n = 1), unrelated (n = 7) and not assessable(n = 12). Although four treatment-related deaths (1%) occurred, grade 3 or 4 late complications were less than 5%. (C) 2004 Elsevier Ltd. All rights reserved.