Treatment of cutaneous leishmaniasis by photodynamic therapy
Treatment of cutaneous leishmaniasis by photodynamic therapy
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DOI：
10.1067/mjd.2003.218
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发表时间：
2003-06-01
影响因子：
13.8
通讯作者：
Fritsch, C
中科院分区：
文献类型：
--
作者：
Gardlo, K;Horska, Z;Fritsch, C
背景皮肤利什曼病是一种常见的健康问题，标准治疗往往无效或效果不佳。目的：比较光动力疗法与硫酸帕罗霉素治疗10例皮肤利什曼病的疗效。方法：采用Metvix （Photocure, Oslo, Norway）和75 J/cm(2)红光对5例病变进行PDT治疗。PDT每周2次，12周后每周1次。其余5个病灶给予硫酸帕罗霉素治疗，每日1次。所有经paromomycin治疗的无反应斑块最后也接受了PDT。结果：经PDT治疗的5个病变和2个经硫酸帕罗霉素治疗的斑块在临床和组织学上均无利什曼原虫。三个对硫酸帕罗霉素反应不佳的病变最终对后续PDT有反应。治疗后10个月无复发，PDT术后美容效果良好。结论：PDT可能是治疗皮肤利什曼病的有效方法。
Background Cutaneous leishmaniasis represents a common health problem and standard treatments are often ineffective or yield poor cosmetic results.Objective: We compared the efficacy of photodynamic therapy (PDT) with paromomycin Sulfate in 10 lesions of cutaneous leishmaniasis.Methods: Five lesions were treated by PDT with Metvix (Photocure, Oslo, Norway) and 75 J/cm(2) red light. PDT was performed twice weekly and, after 12 weeks, once weekly. The other 5 lesions were treated with paromomycin sulfate once daily. All nonresponding lesions of the paromomycin-treated plaques finally also underwent PDT.Results: All 5 lesions treated by PDT and 2 of the paromomycin sulfate-treated plaques were clinically and histologically Leishmania free. Three lesions with poor response to paromomycin Sulfate finally responded to Subsequent PDT. Ten months after therapy there was no recurrence, and cosmetic outcome after PDT was excellent.Conclusion: PDT may be an effective therapeutic alternative in cutaneous leishmaniasis.