Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice.
Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice.
复制标题
乙基麦芽酚和铁络合物对小鼠的毒性研究。
DOI：
10.1155/2017/2640619
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发表时间：
2017
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Li Z;Lu J;Wu C;Pang Q;Zhu Z;Nan R;Du R;Chen J
乙基麦芽酚和铁的络合物是乙基麦芽酚和铁的产物，这些铁存在于用于准备中国菜肴火锅的烹饪锅中。由于其安全性未见文献记载，乙基麦芽酚与铁的络合物在雄性和雌性昆明(KM)小鼠身上进行了毒性研究。这项动物研究是在为确定半数致死剂量(LD50)而进行的初步研究的基础上设计的。研究中使用的剂量分别为溶解于水中的LD_(50)的0、1/81、1/27、1/9和1/3(mg kg Body Weight(BW)−1day−1)。乙基麦芽酚铁配合物对小鼠的经口LD_(50)为743.88 mg kg BW−_1。在90 D口服暴露后，乙基麦芽酚和铁的复合体针对内分泌器官，包括肝脏和肾脏。根据血液学数据，确定乙基麦芽酚铁配合物对雄性和雌性小鼠的最低观察不良反应水平均为1/81LD50(9.18 mg kg bw−1 day−1)。因此，我们建议开发和鼓励替代的火锅制备策略，包括使用非铁基炊具，以避免形成潜在的有毒复合体。
Ethyl maltol and iron complexes are products of ethyl maltol and the iron found in the cooking pots used to prepare the Chinese dish, hot-pot. Because their safety is undocumented, the toxicity study of ethyl maltol and iron complexes was conducted in male and female Kunming (KM) mice. The animal study was designed based on the preliminary study conducted to determine the median lethal dose (LD50). The doses used in the study were 0, 1/81, 1/27, 1/9, and 1/3 of the LD50 (mg kg body weight (BW)−1 day−1) dissolved in the water. The oral LD50 of the ethyl maltol and iron complexes was determined to be 743.88 mg kg BW−1 in mice. The ethyl maltol and iron complexes targeted the endocrine organs including the liver and kidneys following the 90 D oral exposure. Based on the haematological data, the lowest-observed-adverse-effect level (LOAEL) of the ethyl maltol and iron complexes was determined to be 1/81 LD50 (9.18 mg kg BW−1 day−1) in both male and female mice. Therefore, we suggest that alternative strategies for preparing the hot-pot, including the use of non-Fe-based cookware, need to be developed and encouraged to avoid the formation of the potentially toxic complexes.