Peripheral selection of V delta 1+ cells with restricted T cell receptor delta gene junctional repertoire in the peripheral blood of healthy donors.
Peripheral selection of V delta 1+ cells with restricted T cell receptor delta gene junctional repertoire in the peripheral blood of healthy donors.
复制标题
在健康供体的外围血液中，具有受限T细胞受体基因连接库的V Delta 1+细胞的外围选择。
DOI：
10.1084/jem.178.1.121
复制
发表时间：
1993-07-01
影响因子：
15.3
通讯作者：
Sigaux, F
中科院分区：
文献类型：
--
作者：
Beldjord, K;Beldjord, C;Macintyre, E;Even, P;Sigaux, F
To characterize the T cell receptor (TCR) repertoire expressed by the V delta 1+ gamma/delta T cell population, we have studied the V delta 1-J delta 1 junctional sequences from peripheral blood samples of healthy donors. We show that, surprisingly, this repertoire is restricted in most healthy adults, with a donor-specific and relatively stable pattern, whereas this repertoire remains unrestricted in infants, and is similar to that of thymocytes. These data contrast with the general assumption that the junctional repertoire of V delta 1+ gamma/delta T cells is extensive, and strongly suggest that peripheral recruitment of V delta 1+ cells bearing particular TCR occurs in humans during the postnatal stage.
