Mucosal cell proliferation activity of the gallbladder in children with anomalous arrangement of the pancreaticobiliary duct.
Mucosal cell proliferation activity of the gallbladder in children with anomalous arrangement of the pancreaticobiliary duct.
复制标题
胰胆管异常排列儿童胆囊粘膜细胞增殖活性。
DOI：
10.1007/s005340050109
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
N. Iwai
中科院分区：
文献类型：
--
作者：
K. Tokiwa;S. Ono;N. Iwai
胰胆管异常排列（AAPBD）是一种胆管和胰管的解剖学连接异常，常与胆囊癌相关。在患有AAPBD的患者中，已经假定胰液回流到胆道树中，并且回流的胰液和停滞的胆汁的混合物作为胆道上皮的刺激因子，导致慢性炎症和化生。最终，这些粘膜变化可能进展为浸润性癌。我们回顾了AAPBD患者胆囊上皮改变的临床病理学研究，以阐明与癌变相关的意义。传统的组织学研究表明，在患有这种异常的儿童胆囊中观察到的最典型的变化是上皮增生。此外，与胆总管与胰管汇合的儿童（C-P型）相比，胰管与胆总管汇合的儿童（P-C型）胆囊粘膜增生的发生率显著增加。此外，细胞动力学研究表明，AAPBD儿童胆囊细胞增殖活性增加。P-C型AAPBD患儿的细胞增殖活性明显高于C-P型异常患儿。总之，AAPBD可能会增加儿童早期胆囊异常患者的细胞增殖，导致上皮增生。虽然目前尚不清楚哪些药物负责促进细胞功能的激活，但似乎胆汁酸和回流的胰腺蛋白酶可能在这种促进中发挥作用。需要进一步的研究来阐明细胞功能增加的机制。
Anomalous arrangement of the pancreaticobiliary duct (AAPBD) is an anatomical maljunction of the bile duct and the pancreatic duct that is frequently associated with gallbladder carcinoma. In patients with AAPBD, it has been postulated that pancreatic juice regurgitates into the biliary tree, and the mixture of refluxed pancreatic juice and stagnant bile juice acts as an irritant factor to the biliary tract epithelium, leading to chronic inflammation and metaplasia. Eventually these mucosal changes may progress to invasive carcinoma. We reviewed clinicopathologic studies on epithelial changes of the gallbladder in patients with AAPBD to clarify the implications relevant to carcinogenesis. Conventional histological studies have shown that the most characteristic change observed in the gallbladder of children with this anomaly was epithelial hyperplasia. Furthermore, the incidence of mucosal hyperplasia was significantly increased in the gallbladder of children in whom the pancreatic duct joined the common bile duct (P-C type) compared with the incidence in children in whom the common bile duct joined the pancreatic duct (C-P type). In addition, cell kinetic studies have demonstrated increased cellular proliferative activity of the gallbladder in children with AAPBD. Cell proliferative activity was significantly elevated in children with the P-C type of AAPBD compared with that in children with the C-P type of anomaly. In conclusion, AAPBD may yield increased cell proliferation in the gallbladder of patients with this anomaly in early childhood, resulting in epithelial hyperplasia. Although it remains unknown which agents are responsible for promoting the activation of cellular function, it seems that bile acids and refluxed pancreatic proteases are likely play a role in such promotion. Further investigations are needed to elucidate the mechanism of increased cellular function.
鸡胚成纤维细胞的蛋白酶有丝分裂反应和人α-凝血酶的受体结合/加工。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Perdue,JF;Lubenskyi,W;Kivity,E;Sonder,SA;Fenton2nd,JW
通讯作者：
Fenton2nd,JW