Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions
Categorization of cutaneous epithelioid angiomatous nodule as epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia: Clinicopathologic, immunohistochemical, and molecular analyses of seven lesions
复制标题
DOI：
10.1111/cup.14246
复制
发表时间：
2022-05-10
影响因子：
1.7
通讯作者：
Motoi, Toru
中科院分区：
文献类型：
--
作者：
Goto, Keisuke;Ogawa, Kohei;Motoi, Toru
背景皮肤上皮样血管瘤样结节（CEAN）作为一种独特的实体的地位仍然存在争议。本研究探讨CEAN与上皮样血管瘤/血管淋巴样增生伴嗜酸性粒细胞增多症（ALHE）的关系。方法收集4例（病例1-4，分别为61岁、76岁、53岁和21岁男性）7个具有CEAN特征的病灶。结果例1、例2头颈部多发，例3、例4背部、头皮单发。此外，病例1和2的病变的组织病理学表现与传统的上皮样血管瘤或经典的皮肤ALHE一致。例1和例2可见FOSB免疫组织化学染色呈弥漫性表达，但分离荧光原位杂交（FISH）未见FOSB分裂信号。相反，病例3和4的病变的组织病理学表现与细胞型上皮样血管瘤一致。病例3和4中观察到弥漫性c-FOS免疫反应性，病例3中FOS分裂信号在分裂FISH中存在。结论本研究显示7例具有CEAN特征的肿瘤可以重新分类为上皮样血管瘤/ALHE组，尽管样本量小是一个限制。
Background The status of cutaneous epithelioid angiomatous nodule (CEAN) as a distinct entity remains controversial. This study investigated the relationship between CEAN and epithelioid hemangioma/angiolymphoid hyperplasia with eosinophilia (ALHE). Methods Data of seven lesions with CEAN features from four cases (Cases 1-4: 61-year-old, 76-year-old, 53-year-old, and 21-year-old men, respectively) were investigated. Results Cases 1 and 2 showed multiple lesions in the head and neck region, but Cases 3 and 4 showed solitary lesions on the back and scalp, respectively. Moreover, the histopathologic findings of the lesions of Cases 1 and 2 were consistent with those of conventional epithelioid hemangioma or classic cutaneous ALHE. Diffuse immunoexpression of FOSB was observed in Cases 1 and 2, but FOSB split signals were absent in break-apart fluorescence in situ hybridization (FISH). In contrast, the histopathologic findings of the lesions of Cases 3 and 4 were consistent with those of cellular-type epithelioid hemangiomas. Diffuse immunoreactivity for c-FOS was observed in Cases 3 and 4, and split signals of FOS were present in break-apart FISH in Case 3. Conclusions This study showed that the seven tumors with CEAN features could be reclassified under the epithelioid hemangioma/ALHE group, although the small sample size is a limitation.