Parathyroid hormone deficiency with Albright's hereditary osteodystrophy.
Parathyroid hormone deficiency with Albright's hereditary osteodystrophy.
复制标题
甲状旁腺激素缺乏症伴有奥尔布赖特遗传性骨营养不良。
DOI：
10.1210/jcem-39-3-496
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发表时间：
1974
影响因子：
5.8
通讯作者：
Myron Miller
中科院分区：
文献类型：
--
作者：
A. Moses;Janardhana K. Rao;R. Coulson;Myron Miller
摘要Albright描述了一组发生甲状旁腺激素（PTH）抵抗性低钙血症（假性甲状旁腺功能减退症）或正常钙血症（假性甲状旁腺功能减退症）的特征性骨骼变化的患者。报告了一例与这些骨骼变化相关的低钙血症患者。根据低循环PTH水平和正常的尿环磷酸腺苷和磷排泄响应PTH输注，甲状旁腺功能减退症是甲状腺功能缺乏的品种。甲状旁腺激素缺乏症和所谓的假性甲状旁腺功能减退症的结合指出了现有术语中的混乱，并促使我们提出了甲状旁腺激素缺乏症或无反应性疾病的简化分类。甲状旁腺功能减退症应分为激素缺乏型和激素抵抗型。Albright描述的骨骼变化应称为Albright遗传性骨营养不良，可以单独发现或与任何形式的hypoprotein一起发现。
ABSTRACT Albright described a group of patients with characteristic skeletal changes which occurred with parathyroid hormone (PTH)-resistant hypocalcemia (pseudohypoparathyroidism), or which occurred with normocalcemia (pseudopseudohypoparathyroidism). A case is reported of a patient who had hypocalcemia associated with these skeletal changes. On the basis of a low circulating PTH level and normal urinary cyclic AMP and phosphorus excretion in response to PTH infusion, the hypoparathyroidism was the hormone-deficient variety. The combination of PTH deficiency and what has been called pseudo-pseudohypoparathyroidism points out the confusion in the existing terminology, and has led us to propose a simplified classification of diseases of PTH deficiency or unresponsiveness. Hypoparathyroidism should be categorized into hormone-deficient and hormoneresistant forms. The skeletal changes described by Albright should be called Albright's hereditary osteodystrophy and can be found alone or with either form of hyp...