No association of the dopamine D4 receptor (DRD4) and-521 C/T promoter polymorphisms with infant attachment disorganization
No association of the dopamine D4 receptor (DRD4) and-521 C/T promoter polymorphisms with infant attachment disorganization
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DOI：
10.1080/14616730412331281584
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发表时间：
2004-09-01
影响因子：
3.2
通讯作者：
Van Ijzendoorn, MH
中科院分区：
文献类型：
--
作者：
Bakermans-Kranenburg, MJ;Van Ijzendoorn, MH
在第一项分子遗传学研究中，Lakatos 及其同事发现了附着紊乱与多巴胺 D4 受体 (DRD4) 基因多态性之间的关联，特别是在 DRD4 基因启动子区域存在 -521 T 等位基因的情况下。他们的研究在 132 名婴儿样本中进行重复，并未证实 DRD4 7(+) 等位基因和 -521C/T 启动子基因在紊乱附着中的作用。尽管我们的样本更大，并且包含更多具有 CT 或 TT 等位基因的儿童，这提高了发现 DRD4 和 C/T 相互作用的可能性，但并未发现这种关联。即使当我们将我们的样品与 Lakatos 样品组合时，DRD4 和 -521 C/T 多态性对杂乱附着的相互作用效应也不存在。
In a first molecular genetic study Lakatos and colleagues found an association between attachment disorganization and the dopamine D4 receptor (DRD4) gene polymorphism, in particular in the presence of the -521 T allele in the promoter region of the DRD4 gene. Replication of their study in a sample of 132 infants did not confirm the role of the DRD4 7(+) -allele and the -521C/T promoter gene in disorganized attachment. Although our sample was larger, and contained more children with CT or TT alleles, which enhanced the probability of finding the DRD4 and C/T interaction, the association was not found. Even when we combined our sample with the Lakatos sample, the interaction effect of the DRD4 and -521 C/T polymorphisms on disorganized attachment was absent.