Hemodynamic effect of a low-resistance artificial lung in series with the native lungs of sheep.
Hemodynamic effect of a low-resistance artificial lung in series with the native lungs of sheep.
复制标题
低阻力人工肺与绵羊原生肺串联的血流动力学效应。
DOI：
10.1016/s0003-4975(99)01470-8
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Bartlett,RH
中科院分区：
文献类型：
--
作者：
Lynch,WR;Montoya,JP;Brant,DO;Schreiner,RJ;Iannettoni,MD;Bartlett,RH
研究背景人工肺的使用寿命为1 ~ 6个月，可作为移植的桥梁。本文报道了一种无泵人工肺的研制。观察血流动力学，因为右心室通过器械产生血流。通过左胸廓切开术，将两个20 mm移植物以端侧方式固定到肺动脉。将移植物外化，并引导血流通过胸壁到达体外肺。动物被回收，断奶的呼吸机，站立时，流量被转移通过device.ResultsFive的7只动物存活24小时，75%至100%的心输出量通过该设备转移。所有动物都是活跃的，在食物和水的兴趣，并能够station.ConclusionsThe右心室灌注人工肺的75%至100%的心输出量为24小时。该装置证明了依赖于右心室灌注的无泵肺辅助装置的可行性。
BackgroundAn artificial lung with 1 to 6 month work life could act as a bridge to transplantation. A pumpless artificial lung has been developed.MethodsThe artificial lung was placed in series with the native lungs of adult sheep. Hemodynamics were observed, as the right ventricle generated flow through the device. Through a left thoracotomy, two 20-mm grafts were anastomosed in an end-to-side fashion to the pulmonary artery. The grafts were externalized, and directed flow through the chest wall, to the extracorporeal lung. The animals were recovered, weaned from the ventilator, and when standing, flow was diverted through the device.ResultsFive of 7 animals survived 24 hours with 75% to 100% of the cardiac output diverted through the device. All animals were active, with interest in food and water, and able to stand.ConclusionsThe right ventricle perfused the artificial lung with 75% to 100% of the cardiac output for 24 hours. This device demonstrates the feasibility of a pumpless pulmonary assist device relying on the right ventricle for perfusion.