Prefrontal Control of Familiarity and Recollection in Working Memory
Prefrontal Control of Familiarity and Recollection in Working Memory
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DOI：
10.1162/jocn.2009.21252
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发表时间：
2010-02-01
影响因子：
3.2
通讯作者：
Postle, Bradley R.
中科院分区：
文献类型：
--
作者：
Feredoes, Eva;Postle, Bradley R.
左额下回（IFG）是解决工作记忆中前摄干扰（PI）的关键神经基质。我们假设，左IFG实现这一点，通过控制的影响，熟悉与回忆为基础的信息的记忆探针。与这一想法一致，我们观察到的证据，早期（200毫秒）的峰值信号对应的记忆探针熟悉和后期（500毫秒）解决信号对应的试验相关的上下文（“回忆为基础的”）信息的充分积累。接下来，我们将短暂的重复经颅磁刺激（rTMS）时间锁定到这些记忆信号，左IFG和控制区域。只有左侧IFG的早期rTMS产生了高PI探头虚警率的调制。此外，这种影响的程度是由PI敏感性的个体差异预测的。这些结果表明，左IFG为基础的控制可能会偏见的熟悉和回忆为基础的信号的影响，再认决策。
Left inferior frontal gyrus (IFG) is a critical neural substrate for the resolution of proactive interference (PI) in working memory. We hypothesized that left IFG achieves this by controlling the influence of familiarity-versus recollection-based information about memory probes. Consistent with this idea, we observed evidence for an early (200 msec)-peaking signal corresponding to memory probe familiarity and a late (500 msec)-resolving signal corresponding to full accrual of trial-related contextual ("recollection-based") information. Next, we applied brief trains of repetitive transcranial magnetic stimulation (rTMS) time locked to these mnemonic signals, to left IFG and to a control region. Only early rTMS of left IFG produced a modulation of the false alarm rate for high-PI probes. Additionally, the magnitude of this effect was predicted by individual differences in susceptibility to PI. These results suggest that left IFG-based control may bias the influence of familiarity and recollection-based signals on recognition decisions.