Distributed versus compartment models for PET receptor studies
Distributed versus compartment models for PET receptor studies
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DOI：
10.1109/tmi.2002.806576
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发表时间：
2003-01-01
影响因子：
10.6
通讯作者：
Saidel, GM
中科院分区：
文献类型：
--
作者：
Muzic, RF;Saidel, GM
尽管分布式模型通常被认为比隔室模型更真实，但更简单的隔室模型在核医学应用中普遍使用，特别是在正电子发射断层扫描 (PET) 中。在这里，我们报告了分布式模型和区室模型输出之间的比较，以解决它们之间的差异是否足以证明用于分析 PET 受体实验的分布式模型的合理性的问题。对于两次和三次注射实验，“数据”集是通过使用分布式模型和广泛的参数值进行模拟获得的。通过估计不同参数组的值的三种策略实现了室模型输出与这些“数据”的最佳拟合。房室模型输出与所有分布式模型输出产生良好的拟合，并且相应参数的值非常一致。考虑到 PET 通常具有的时间分辨率，使用分布式模型进行 PET 受体定量并不比隔室模型有任何优势。
Although distributed models are generally accepted as being more realistic than compartment models, use of simpler compartment models is pervasive in nuclear medicine applications, particularly in positron emission tomography (PET). Here, we report on comparisons made between distributed and compartment model outputs to address the question of whether differences between them are sufficient to justify distributed models for analysis of PET receptor experiments. For both two- and three-injection experiments, "data" sets were obtained by simulation using a distributed model and a wide range of parameter values. Optimal fits of the compartment model output to these "data" were achieved with three strategies in which values of different groups of parameter were estimated. Compartment model outputs yielded good fits to all the distributed model outputs and the values of the corresponding parameters were in close agreement. Given the temporal resolution typically available with PET, the use of a distributed model has no advantage over a compartment model for PET receptor quantification.