Through the looking glass: Differential noradenergic modulation of prefrontal cortical function
Through the looking glass: Differential noradenergic modulation of prefrontal cortical function
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DOI：
10.1155/np.2000.133
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发表时间：
2000-01-01
影响因子：
3.1
通讯作者：
Simon, F
中科院分区：
文献类型：
--
作者：
Arnsten, AFT;Simon, F
长期以来，人们一直认为去甲肾上腺素增强了对感觉刺激的“信号/噪声”处理(Foote等人，1975；西格尔和布鲁姆，1976；Water-house等人，1998)。沃特豪斯和他的同事(沃特豪斯等人，1980年；沃特豪斯等人，1981年；穆拉迪安等人，1991年)剖析了这些效应背后的受体机制，发现β肾上腺素能受体刺激可以增强抑制反应，而α-1肾上腺素能受体刺激可以增强兴奋反应。这样的影响已经在大脑的不同区域观察到，包括听觉和躯体感觉皮质、小脑和海马体。例如，听觉皮质神经元的感受场属性通过α-1受体机制被锐化(Manunta&Edeline，1997)，而小脑神经元的视场属性受β受体机制的调节(Moise等人，1990)。
It has long been appreciated that NE enhances the" signal/noise" processing of sensory stimuli (Foote et al., 1975; Segal & Bloom, 1976; Water-house et al., 1998). Waterhouse and colleagues (Waterhouse et al., 1980; Waterhouse et al., 1981; Mouradian et al., 1991) dissected the receptor mechanisms underlying these effects and found that beta adrenergic receptor stimulation can enhance inhibitory responses, whereas alpha-1 adrenergic receptor stimulation can enhance excitatory responses. Such effects have been observed in a variety ofbrain regions, including auditory and somatosensory cortices, cerebellum, and hippocampus. For example, the receptive field properties of auditory cortical neurons are sharpened through an alpha-1 receptor mechanism (Manunta & Edeline, 1997), whereas the Visual field properties of eerebellar neurons are modulated by a beta receptor mechanism (Moises et al., 1990).