Gustatory and metabolic perception of nutrient stress in Drosophila
Gustatory and metabolic perception of nutrient stress in Drosophila
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DOI：
10.1073/pnas.1401501112
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发表时间：
2015-02-24
影响因子：
11.1
通讯作者：
Pletcher, Scott D.
中科院分区：
文献类型：
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作者：
Linford, Nancy J.;Ro, Jennifer;Pletcher, Scott D.
睡眠不足是对营养缺乏的一种适应性反应，它会改变行为，以最大限度地提高死亡前进食的机会。生物体必须保持检测食物来源质量的系统，以便在压力减轻时恢复健康的睡眠水平。我们确定，当动物遇到营养不良的食物来源时，甜味的味觉感知是必要的，也足以抑制饥饿引起的睡眠丧失。我们进一步发现，阻断特定的多巴胺能神经元表现为味觉刺激的缺乏，这表明这些神经元在将味觉信息传导到大脑睡眠中心中的特定作用。最后，我们表明，味觉感知是生存所必需的，特别是在低营养环境中。总的来说，这些结果表明，味觉感知环境食物供应接近零时的重要作用，并说明了感官和代谢感知的营养物质供应之间的相互作用，在调节行为状态。
Sleep loss is an adaptive response to nutrient deprivation that alters behavior to maximize the chances of feeding before imminent death. Organisms must maintain systems for detecting the quality of the food source to resume healthy levels of sleep when the stress is alleviated. We determined that gustatory perception of sweetness is both necessary and sufficient to suppress starvation-induced sleep loss when animals encounter nutrient-poor food sources. We further find that blocking specific dopaminergic neurons phenocopies the absence of gustatory stimulation, suggesting a specific role for these neurons in transducing taste information to sleep centers in the brain. Finally, we show that gustatory perception is required for survival, specifically in a low nutrient environment. Overall, these results demonstrate an important role for gustatory perception when environmental food availability approaches zero and illustrate the interplay between sensory and metabolic perception of nutrient availability in regulating behavioral state.