Childhood astrovirus-associated diarrhea in the ambulatory setting in a Public Hospital in Cordoba city, Argentina
Childhood astrovirus-associated diarrhea in the ambulatory setting in a Public Hospital in Cordoba city, Argentina
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DOI：
10.1590/s0036-46652004000200007
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发表时间：
2004-04-01
期刊：
影响因子：
--
通讯作者：
Nates, Silvia V.
中科院分区：
文献类型：
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作者：
Giordano, Miguel O.;Martinez, Laura C.;Nates, Silvia V.
越来越多的人星状病毒被认为是儿童腹泻病的重要病原体。然而，禽流感病毒感染的疾病负担仍然没有完全评估。本文报道了阿根廷科尔多瓦市一家公立医院星状病毒相关腹泻的流行病学和临床特征，以及星状病毒感染对门诊环境的影响。从2001年2月至2002年1月，97名随机选择的36个月大的腹泻儿童门诊就诊。从每个孩子的粪便中收集一份标本，并通过酶免疫测定法检测星状病毒抗原。星状病毒检出率为12.37%。所有阳性病例均发生在4 ~ 18个月，但以4 ~ 6个月最高（23.80%）。星状病毒相关性腹泻的临床表现为发热41.66%、呕吐25.00%、脱水8.33%，住院率16.66%。星状病毒在全年都有发现，没有发现季节性模式（凉爽季节15.21%，温暖季节9.80%，p > 0.05）。根据我们的估计，在这个队列中，大约每74名儿童中就有一名每年在公立医院接受星状病毒-腹泻治疗，每8名腹泻病例中就有一名可归因于星状病毒感染。星状病毒是研究地区公立医院儿科门诊常见的症状性感染，占腹泻总发病率的12.37%。
Human astroviruses have been increasingly identified as important agents of diarrhea) disease in children. However, the disease burden of asnrovirus infection is still incompletely assessed. This paper reports results on the epidemiological and clinical characteristics of astrovirus-associated diarrhea, as well as the impact of astrovirus infection on the ambulatory setting at a Public Hospital in Cordoba city, Argentina. From February 2001 through January 2002, 97 randomly selected outpatient visits for diarrhea among children 36 months old were enrolled. A single specimen of stool from each child was collected and tested for astrovirus antigen by enzyme immunoassay. Astroviruses were detected in 12.37% of the diarrheal episodes. All the positive cases occurred in children 4 to 18 months, but the highest rate was in children aged 4 to 6 months (23.80%). The clinical symptoms of astrovirus associated-diarrhea were fever 41.66%, vomiting 25.00% and dehydration 8.33%; overall 16.66% required hospitalization. Astrovirus was identified through the year and no seasonally pattern was detected (cool semester 15.21% versus warm semester 9.80% p > 0.05). According to our estimation about one out of seventy-four children in this cohort would be assisted annually for an astroviral-diarrheal episode in the Public Hospital and one out of eight diarrhea) cases could be attributed to astrovirus infection. Astrovirus is a common symptomatic infection in pediatric outpatient visits in the public hospital in the study area, contributing 12.37% of the overall morbidity from diarrhea.