Brief Report: Natural History of Individuals With Clinically Recognized Monoclonal B-Cell Lymphocytosis Compared With Patients With Rai 0 Chronic Lymphocytic Leukemia
Brief Report: Natural History of Individuals With Clinically Recognized Monoclonal B-Cell Lymphocytosis Compared With Patients With Rai 0 Chronic Lymphocytic Leukemia
复制标题
DOI：
10.1200/jco.2008.21.2704
复制
发表时间：
2009-08-20
影响因子：
45.3
通讯作者：
Hanson, Curtis A.
中科院分区：
文献类型：
--
作者：
Shanafelt, Tait D.;Kay, Neil E.;Hanson, Curtis A.
目的单克隆 B 细胞淋巴细胞增多症 (MBL) 的诊断用于表征患者的循环克隆 B 细胞群、B 细胞总数低于 5 X 10(9)/L，并且不存在 B 细胞淋巴增殖性疾病的其他特征，包括淋巴结肿大/器官肿大。临床鉴定的 MBL 的自然史尚不清楚。本研究的目的是探讨 MBL 患者相对于 Rai 0 期慢性淋巴细胞白血病 (CLL) 个体的结果。患者和方法我们使用血液病理学记录来确定 631 名新诊断 MBL 或 Rai 0 期 CLL 患者的队列。在该队列中，302 名患者患有 MBL（B 细胞计数为 0.02 至 4.99 X 10(9)/L）； 94 名患者患有 Rai 0 期 CLL，且具有绝对淋巴细胞计数 (ALC)
PurposeThe diagnosis of monoclonal B-cell lymphocytosis (MBL) is used to characterize patients with a circulating population of clonal B cells, a total B-cell count of less than 5 X 10(9)/L, and no other features of a B-cell lymphoproliferative disorder including lymphadenopathy/organomegaly. The natural history of clinically identified MBL is unclear. The goal of this study was to explore the outcome of patients with MBL relative to that of individuals with Rai stage 0 chronic lymphocytic leukemia (CLL).Patients and MethodsWe used hematopathology records to identify a cohort of 631 patients with newly diagnosed MBL or Rai stage 0 CLL. Within this cohort, 302 patients had MBL (B-cell counts of 0.02 to 4.99 X 10(9)/L); 94 patients had Rai stage 0 CLL with an absolute lymphocyte count (ALC)