Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density
Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density
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DOI：
10.1359/jbmr.041110
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发表时间：
2005-02-01
影响因子：
6.2
通讯作者：
Armamento-Villareal, R
中科院分区：
文献类型：
--
作者：
Napoli, N;Villareal, DT;Armamento-Villareal, R
在这项研究中，我们评估了与激素相关癌症相关的CYP1A1基因的多态对雌激素代谢和骨密度的影响。我们发现，携带C4887A多态A等位基因(CA和AA)的变种具有显著更高的雌激素分解代谢程度和更低的股骨骨密度。
In this study, we evaluated the effect of polymorphisms of the CYP1A1 gene, linked to hormone-related cancers, on estrogen metabolism and BMD. We found that variants carrying the A allele (CA and AA) for the C4887A polymorphism have a significantly higher degree of estrogen catabolism and lower femoral BMD.