Differences in the Prevalence of Dementia and Mild Cognitive Impairment and Cognitive Functions between Early and Delayed Responders in a Community-Based Study of the Elderly
Differences in the Prevalence of Dementia and Mild Cognitive Impairment and Cognitive Functions between Early and Delayed Responders in a Community-Based Study of the Elderly
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DOI：
10.3233/jad-130398
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Yamada, Masahito
中科院分区：
文献类型：
--
作者：
Noguchi-Shinohara, Moeko;Yuki, Sohshi;Yamada, Masahito
在基于人群的心理健康和认知状态研究中，应答者和非应答者之间的人口统计学特征存在显著差异，但关于他们之间痴呆和认知功能障碍患病率的差异知之甚少。在此，我们在一项针对日本老年公民（>= 65岁）的调查中，比较了群体脑功能检查的早期应答者和延迟应答者（群体脑功能检查的无应答者）之间痴呆和轻度认知障碍的患病率，以评估无应答者偏倚。日本中岛地区的所有居民被认为是潜在的候选人（n = 783）。参加集体脑功能检查的人被认为是“早期反应者”。“通过家访评估了延迟应答者的认知功能。为了评估社会人口学特征和认知功能之间的相关性，早期和延迟应答者完成了相同的问卷调查和神经心理学测试。延迟应答者（n = 320）明显比早期应答者（n = 307）年龄大，受教育程度低。与早期反应者相比，延迟反应者也表现出更高的痴呆和轻度认知障碍频率，即使这些群体仅限于65-89岁的年龄组。我们的研究结果表明，基于人群的研究可能低估了痴呆症和轻度认知障碍的患病率，特别是如果参与率较低。
Significant differences exist in demographic characteristics between responders and non-responders in population-based studies on mental health and cognitive status, but much less is known regarding differences in the prevalence of dementia and cognitive dysfunction between them. Here we compared the prevalence of dementia and mild cognitive impairment between early responders of a mass brain function examination and delayed responders (non-responders of the mass brain function examination) in a survey of elderly Japanese citizens (>= 65 years) to evaluate non-responder bias. All residents in an area of Nakajima, Japan, were considered as potential candidates (n = 783). Participants of a mass brain function examination were considered as "early responders." The cognitive functions of delayed responders were assessed by home visits. To assess the correlation between sociodemographic characteristics and cognitive functions, the early and delayed responders completed the same questionnaires and neuropsychological tests. Delayed responders (n = 320) were significantly older and less educated than the early responders (n = 307). The delayed responders also exhibited a higher frequency of dementia and mild cognitive impairment than the early responders, even when the groups were restricted to the age group 65-89 years. Our results suggest that population-based studies likely underestimate the prevalence of dementia and mild cognitive impairment, especially if the participation rate is low.