Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.
Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.
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Daphnepedunins G 和 H，来自 Daphne pedunculata 的抗 HIV 大环 3,4-seco-daphnane 原酸酯。
DOI：
10.1007/s11418-023-01750-6
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发表时间：
2024
影响因子：
3.3
通讯作者：
Li,Wei
中科院分区：
文献类型：
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作者：
Tan,Lingjian;Otsuki,Kouharu;Zhang,Mi;Kikuchi,Takashi;Zhou,Di;Li,Ning;Huang,Li;Chen,Chin-Ho;Li,Wei
从长柄石楠中分离到具有特殊大环3,4-邻石楠正构酯结构的石楠苷G(1)和H(2)。通过物理化学和光谱分析，结合甲基酯化、手性各向异性衍生化反应和仿生转化等合成方法确定了它们的结构。对化合物1和2及其甲酯1和2的抗hiv活性进行了评价，其中化合物1和2的ic50值分别为1.08 μM和1.17 μM，具有较强的抗hiv活性。图形抽象
Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated fromDaphne pedunculata. Their structures were determined by physicochemical and spectroscopic analyses combined with synthetic methods, including methyl esterification, derivatization reaction using a chiral anisotropic agent, and biomimetic conversion. Compounds1and2along with their methyl esters1aand2awere evaluated for anti-HIV activity, among which1aand2aexhibited potent activity with IC50values of 1.08 and 1.17 μM, respectively.Graphical abstract