Association of the CD36 gene with impaired glucose tolerance, impaired fasting glucose, type-2 diabetes, and lipid metabolism in essential hypertensive patients.
Association of the CD36 gene with impaired glucose tolerance, impaired fasting glucose, type-2 diabetes, and lipid metabolism in essential hypertensive patients.
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DOI：
10.4238/2012.july.10.2
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发表时间：
2012-08
期刊：
影响因子：
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通讯作者：
Y. Wang;X. Zhou;Y. Zhang;P. Gao;D. Zhu
中科院分区：
文献类型：
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作者：
Y. Wang;X. Zhou;Y. Zhang;P. Gao;D. Zhu
原发性高血压是一种常见的疾病，可增加2型糖尿病（T2 D）的风险。CD 36在糖尿病和高血压患者中已被广泛研究;然而，很少有研究关注CD 36基因与原发性高血压患者中空腹血糖受损（IFG）/糖耐量受损（IGT）或T2 D的关系。为了确定CD 36基因中rs 1049673和rs 1527483与IFG/IGT和T2 D易感性的关系，我们对1257例汉族原发性高血压患者进行了病例对照研究（对照组：676例; IGT/IFG：468例; T2 D：113例）。我们还评估了两个位点对胰岛素敏感性、糖耐量和血脂的影响。本研究的主要发现是rs 1049673与原发性高血压患者IFG/IGT和T2 D相关（Pco = 0.028; Pdom = 0.015）。rs 1049673 G携带者的Glu 0（βdom = 0.08（0.01~0.16），Pdom = 0.045）和Lp（a）（βco = 0.04（0.002~0.07），Pco = 0.041;校正性别、年龄、BMI和平均血压后，线性回归分析显示，βdom = 0.06（0.01~0.12），Pdom = 0.032），HDL较低。提示CD 36基因可能在原发性高血压患者IFG/IGT和T2 D的发病中起一定作用。
Essential hypertension is a common disorder that can increase the risk of type 2 diabetes (T2D). CD36 has been studied in patients with diabetes and hypertension extensively; however, few studies have focused on the relationship of the CD36 gene with impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) or T2D in essential hypertension patients. To identify rs1049673 and rs1527483 in the CD36 gene conferring susceptibility to IFG/IGT and T2D, we conducted a case-control study in 1257 essential hypertension patients among the Han Chinese population (control: 676; IGT/IFG: 468; T2D: 113). We also evaluated the impact of two loci on insulin sensitivity, glucose tolerance and serum lipid. The major findings of this study were that rs1049673 was found associated with IFG/IGT and T2D in essential hypertension patients (Pco = 0.028; Pdom = 0.015). The rs1049673 G carriers showed significant higher Glu0 (βdom = 0.08 (0.01~0.16), Pdom = 0.045) and Lp(a) (βco = 0.04 (0.002~0.07), Pco = 0.041; βdom = 0.06 (0.01~0.12), Pdom = 0.032), and lower HDL by the linear regression with the adjustment for gender, age, BMI, and mean blood pressures. These findings provided evidence that the CD36 gene may play some role in the pathogenesis of IFG/IGT and T2D in essential hypertension patients.