G-protein activation decreases isoflurane inhibition of N-type Ba2+ currents.
G-protein activation decreases isoflurane inhibition of N-type Ba2+ currents.
复制标题
G 蛋白激活可减少异氟烷对 N 型 Ba2 电流的抑制。
DOI：
10.1097/00000542-200308000-00021
复制
发表时间：
2003
期刊：
影响因子：
8.8
通讯作者：
Recio-Pinto,Esperanza
中科院分区：
文献类型：
--
作者：
Nikonorov,IgorM;Blanck,ThomasJJ;Recio-Pinto,Esperanza
背景：G蛋白激活介导N型钙电流的抑制。挥发性麻醉剂在不同水平上影响G-蛋白通路，并且G-蛋白的活化已显示出增加挥发性麻醉剂抑制回肠中的电诱导收缩的效力。作者研究了异氟烷对N型Ba 2电流的抑制是否由G蛋白激活介导。研究方法：用全细胞电压灯法测定了人神经元SH-SY 5 Y细胞N-型Ba_2电流。
Background: G-protein activation mediates inhibition of N-type Ca2 currents. Volatile anesthetics affect G-protein pathways at various levels, and activation of G-proteins has been shown to increase the volatile anesthetic potency for inhibiting the electrical-induced contraction in ileum. The authors investigated whether isoflurane inhibition of N-type Ba2 currents was mediated by G-protein activation. Methods: N-type Ba2 currents were measured in the human neuronal SH-SY5Y cell line by using the whole cell voltageclamp method.Results: Isoflurane was found to have two effects on N-type