Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls.
Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls.
复制标题
DOI：
10.1016/j.pnpbp.2010.11.001
复制
发表时间：
2011-07-01
影响因子：
5.6
通讯作者：
Lin Z
中科院分区：
文献类型：
--
作者：
Xu M;Lin Z
以往的遗传关联研究报道了多巴胺转运蛋白（DAT，基因符号：SLC6A3）基因在酒精依赖病因学中的可能作用，但结果相互矛盾。我们对已发表的以人群为基础的病例对照遗传学研究进行了汇总分析，这些研究调查了SLC6A3多态性与酒精依赖之间的关联。我们还通过分层分析探讨了地理区域、种族、性别和诊断标准是否会调节任何相关性。通过对13项研究的2483例病例和1753例对照的分析，发现SLC6A3基因3′非翻译区40个碱基对的可变数目串联重复序列（VNTR）多态性在总体上或按地理区域、种族、性别和诊断标准进行的分层分析中均未显示与酒精依赖有任何关联。由于有限的研究集中在SLC6A3基因的其他区域的多态性，我们不能排除SLC6A3基因参与酒精依赖的遗传风险的作用。进一步阐明SLC6A3在酒精依赖易感性中的遗传作用应该集中在SLC6A3基因的其他潜在功能区域。
Previous genetic association studies have reported a possible role of the dopamine transporter (DAT, gene symbol: SLC6A3) gene in the etiology of alcohol dependence, but the results were conflicting with each other. We conducted a pooled analysis of published population-based case–control genetic studies investigating associations between polymorphisms in SLC6A3 and alcohol dependence. We also explored whether geographic area, ethnicity, gender, and diagnostic criteria moderated any association by using stratified analysis. Through combining 13 studies with 2483 cases and 1753 controls, the 40-base pair variable number tandem repeat (VNTR) in the 3′ un-translated region, the well studied polymorphism in SLC6A3, did not show any association with alcohol dependence in general or in stratified analyses according to geographic area, ethnicity, gender, and diagnostic criteria. Due to limited studies focused on polymorphisms in other regions of the SLC6A3 gene, we cannot rule out the role of the SLC6A3 gene in the involvement of the genetic risk of alcohol dependence. Further clarification of the genetic role of SLC6A3 in the susceptibility to alcohol dependence should be centered on other potential functional regions of the SLC6A3 gene.