STRUCTURE AND BIOSYNTHESIS OF MELANIN-CONCENTRATING HORMONE
STRUCTURE AND BIOSYNTHESIS OF MELANIN-CONCENTRATING HORMONE
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DOI：
10.1016/0024-3205(89)90500-6
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发表时间：
1989-01-01
期刊：
影响因子：
6.1
通讯作者：
KAWAUCHI, H
中科院分区：
文献类型：
--
作者：
KAWAUCHI, H
黑色素浓缩激素是硬骨鱼下丘脑产生并转移到神经垂体的神经肽。鲑鱼 MCH 是一种新型环状十七肽，能够在所有测试的硬骨鱼中以皮纳摩尔浓度诱导外皮黑素细胞黑色素聚集。 MCH基因无内含子，外显子编码132个氨基酸的前体蛋白，其中MCH的十七肽位于C末端。使用抗鲑鱼 MCH 抗血清进行的免疫组织化学研究强烈表明，高等脊椎动物的下丘脑中存在 MCH 样肽。人们发现鲑鱼 MCH 对其他脊椎动物的生物效应是多方面的。
Melanin-concentrating hormone is a neuropeptide produced in teleost hypothalami and transferred to the neurohypophysis. Salmon MCH was a novel cyclic heptadecapeptide capable of inducing melanin aggregation of integumentary melanophores at picoto nano-molar concentrations in all teleosts tested. The MCH gene is intronless and the exon encodes a 132 amino acid precursor protein, in which the heptadecapeptide of MCH locates at the C-terminal end. Immunohistochemical surveys with anti-salmon MCH antiserum strongly suggest that an MCH-like peptide is present in the hypothalami of higher vertebrates. Biological effects of salmon MCH on other vertebrates are found to be versatile.