Histamine food poisoning: a sudden, large outbreak linked to fresh yellowfin tuna from Reunion Island, France, April 2017
Histamine food poisoning: a sudden, large outbreak linked to fresh yellowfin tuna from Reunion Island, France, April 2017
复制标题
DOI：
10.2807/1560-7917.es.2019.24.22.1800405
复制
发表时间：
2019-05-30
期刊：
影响因子：
19
通讯作者：
de Santi, Vincent Pommier
中科院分区：
文献类型：
--
作者：
Velut, Guillaume;Delon, Francois;de Santi, Vincent Pommier
2017年4月20日，位于巴黎附近的法国军事单位发生组胺食物中毒事件。共发现40例（发病率：16.6%）。我们对31例病例和63名对照进行了病例对照研究。多变量分析指出，煮熟的黄鳍金枪鱼鱼片很可能是食物中毒的来源（比值比=156.8; 95%置信区间：18.4- 1，338.4）。新鲜的黄鳍金枪鱼来自留尼汪岛，在巴黎的主要食品市场真空密封并用冰包装。在上游和下游供应链中不存在冷链问题。在吃剩的生金枪鱼中发现组胺浓度为1，720毫克/千克，在对照的熟金枪鱼中发现组胺浓度为3，720毫克/千克，远高于欧洲法规规定的阈值（200毫克/千克）。在剩下的生金枪鱼中确认存在变栖克雷伯氏菌和成团泛菌，这两种微生物属于肠球菌目，据报道可产生组胺。这种类型的食物中毒很少被发现和确认。我们描述的爆发，以突出这种类型的调查的具体要点。
On 20 April 2017, an outbreak of histamine food poisoning occurred in a French military unit located near Paris. A total of 40 cases were identified (attack rate: 16.6%). We conducted a case-control study on 31 cases and 63 controls. Multivariate analysis pointed to cooked yellowfin tuna fillet as the very likely source of food poisoning (odds ratio =156.8; 95% confidence interval: 18.4-1,338.4). The fresh yellowfin tuna was from Reunion Island and was supplied vacuum-sealed and packed with ice at the principal food market of Paris. No cold chain issues could be established in the upstream and downstream supply chains. Histamine concentration was found to be 1,720 mg/kg in leftover raw tuna, and 3,720 mg/kg in control cooked tuna, well above the threshold limit values defined by European regulations (200 mg/kg). The presence of Klebsiella variicola and Pantoea agglomerans, microorganisms of the Enterobacterales order that have been reported to produce histamine, was confirmed in the leftover raw tuna. This type of food poisoning is rarely recognised and confirmed. We describe the outbreak to highlight the specific key points of this type of investigation.