Development of the retinal vasculature
Development of the retinal vasculature
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DOI：
10.1007/s10456-007-9065-1
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发表时间：
2007-01-01
期刊：
影响因子：
9.8
通讯作者：
Fruttiger, Marcus
中科院分区：
文献类型：
--
作者：
Fruttiger, Marcus
供应视网膜内部的血管在发育过程中进行了广泛的重组。血管退行性变、新生血管生成、血管重塑和血管分化事件在很大程度上依赖于神经元、神经胶质细胞、内皮细胞、周细胞和免疫细胞等不同细胞成分之间的细胞-细胞信号转导。使用转基因和基因缺失方法对小鼠进行的研究已经开始揭开其中一些信号通路的遗传基础，并导致对控制视网膜血管发育过程和病理条件下行为的分子机制的理解有了很大改善。这种洞察力将为未来旨在操纵视网膜血管的治疗方法提供基础。
Blood vessels that supply the inner portion of the retina are extensively reorganized during development. The vessel regression, sprouting angiogenesis, vascular remodelling and vessel differentiation events involved critically depend on cell-cell signalling between different cellular components such as neurons, glia, endothelial cells, pericytes and immune cells. Studies in mice using transgenic and gene deletion approaches have started to unravel the genetic basis of some of these signalling pathways and have lead to a much improved understanding of the molecular mechanisms controlling retinal blood vessel behaviour both during development and under pathological conditions. Such insight will provide the basis of future therapeutic approaches aimed at manipulating retinal blood vessels.