Isolation of a New Indole Alkaloid, Pendolmycin, from Nocardiopsis
Isolation of a New Indole Alkaloid, Pendolmycin, from Nocardiopsis
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从诺卡氏菌中分离出一种新的吲哚生物碱——喷多霉素
DOI：
10.1021/np50060a022
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发表时间：
1988
影响因子：
5.1
通讯作者：
K. Umezawa
中科院分区：
文献类型：
--
作者：
T. Yamashita;M. Imoto;K. Isshiki;T. Sawa;H. Naganawa;S. Kurasawa;B. Zhu;K. Umezawa
从拟诺卡氏菌属菌株SA 1715中分离到一种新的吲哚生物碱pendolmycin [1]，它是表皮生长因子诱导的A431细胞磷脂酰肌醇转换的抑制剂。彭多霉素的结构与杀鱼素B [2}和林贝毒素A [3]的结构密切相关。在筛选表皮生长因子（EGF）诱导的磷脂酰肌醇转换酶的过程中，我们从拟诺卡氏菌（Nocardiopsis）中分离到一个新的吲哚生物碱，命名为pendolmycin [1]。本文报道了该化合物的分离、纯化和结构测定，并证明它的结构是一种新的吲哚生物碱。
A new indole alkaloid, pendolmycin [1], was isolated from Nocardiopsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B [2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.In the course of screening for inhibitorsof epidermal-growth-factor (EGF)-induced phosphatidylinositol turnover, we have isolated a new indole alkaloid from a strain of Nocardiopsis, which we named pendolmycin [1], We report here the isolation, purifica-tion, and structure determination of this compound and show that it is structurally