Overview of AA and Research Progress: What Have We Learned and Where Are We Headed?
Overview of AA and Research Progress: What Have We Learned and Where Are We Headed?
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AA 概述和研究进展：我们学到了什么以及我们将走向何方？
DOI：
10.1038/jidsymp.2015.30
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Norris,DavidA
中科院分区：
文献类型：
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作者：
Norris,DavidA
在其成立25周年之际，国家斑秃基金会承担了一个项目，以彻底重新评估他们的研究计划，并帮助集中和指导斑秃研究的未来方向，以更好地满足斑秃患者（AA）和科学家的目标，以发现疾病的机制和更好的治疗方法。该项目体现在2008年、2009年、2010年和2012年的四次研究峰会上，作为基金会主要战略倡议的一部分，斑秃治疗发展计划加速了可行的斑秃治疗的进展。第一次峰会是对全球意义上的AA研究进展的评估，重点是如何利用研究项目为患者带来更好的治疗。第二场峰会的重点是免疫学以及如何更好地理解AA的自身免疫本质。第三次峰会的重点是建立一个能够最有效地为患者带来新疗法的临床研究网络。第四次峰会巩固了大量关于AA机制的证据，以及这些机制如何被现代疗法靶向，其中许多疗法已被有效地用于其他自身免疫性疾病。这四次峰会为该系列的第五次峰会奠定了基础：从目标到治疗：桥接自身免疫研究以促进对斑秃的了解。
During its 25th anniversary year, the National Alopecia Areata Foundation undertook a project to completely re-evaluate their research program and to help focus and direct future directions of alopecia areata research to better meet the goals of people with alopecia areata (AA) and the scientists working to discover mechanisms of disease and better treatments for AA. This project was embodied in four research summits in 2008, 2009, 2010, and 2012, as part of the Foundation’s main strategic initiative, the Alopecia Areata Treatment Development Program to accelerate progress toward a viable alopecia areata treatment. The first summit was an evaluation of the progress of AA research in a global sense, with an emphasis on how to use the research programs to bring better treatments to patients. The second summit focused on immunology and how to better understand the autoimmune nature of AA. The third summit focused on developing a clinical research network that could most effectively bring new treatments to patients. The fourth summit consolidated the considerable evidence of the mechanisms of AA, and how these mechanisms could be targeted by modern therapies, many of which were being used effectively in other autoimmune diseases. These four summits laid the foundation for the fifth summit in the series:From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata.