Depression as a prognostic factor for breast cancer mortality
Depression as a prognostic factor for breast cancer mortality
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DOI：
10.1176/appi.psy.44.1.24
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发表时间：
2003-01-01
期刊：
影响因子：
3.4
通讯作者：
Jorgensen, T
中科院分区：
文献类型：
--
作者：
Hjerl, K;Andersen, EW;Jorgensen, T
目前尚不清楚抑郁或抑郁症状是否对乳腺癌患者的死亡率有影响。在丹麦进行的这项基于人群的全国性回顾性队列研究中，抑郁症被定义为需要住院治疗的有效或焦虑性疾病。所有的情感和焦虑障碍被分为五个顺序诊断组。早期（N= 10，382）和晚期（N= 10，211）乳腺癌患者分别进行分析，考克斯回归调整，充分记录的躯体预后变量。作者使用了来自三个中央登记处的数据的生存分析，发现患有抑郁症的乳腺癌患者的死亡风险适度但显着较高，这取决于乳腺癌的分期和抑郁的时间。在排除了意外、自杀或他杀等非自然死亡原因后，也发现了同样的结果。
It is unclear if depression or depressive symptoms have an effect on mortality in breast cancer patients. In this population-based, nationwide, retrospective cohort study in Denmark, depression was defined as effective or anxiety disorders that necessitated psychiatric hospital admission. All the affective and anxiety disorders were divided and categorized into five ordinal diagnostic groups. Early-stage (N= 10,382) and late-stage (N= 10,211) breast cancer patients were analyzed separately with Cox's regression adjusted,for well-documented somatic prognostic variables. The authors used survival analysis of data from three central registers and found that breast cancer patients with depression had a modestly but significantly higher risk of mortality depending on stage of breast cancer and time of depression. The same result was found after censoring unnatural causes of death such as accident, suicide, or homicide.