Anatomical MRI with an atomic magnetometer
Anatomical MRI with an atomic magnetometer
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DOI：
10.1016/j.jmr.2013.02.020
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发表时间：
2013-06-01
影响因子：
2.2
通讯作者：
Karaulanov, T.
中科院分区：
文献类型：
--
作者：
Savukov, I.;Karaulanov, T.
超低场 (ULF) MRI 是一种很有前途的廉价医学成像方法，与传统仪器相比具有多种额外优势，例如重量轻、功耗低、便携、无金属伪影和高对比度。解剖超低频 MRI 已成功使用 SQUID 实施，但 SQUID 存在需要冷冻剂的缺点。原子磁力计的灵敏度与 SQUID 相当，原则上可以用于 ULF MRI 来替代 SQUID。不幸的是，由于原子磁力计对磁场和梯度的敏感性，存在一些问题。在低频下，噪声也很大，需要屏蔽室来提高灵敏度。在本文中，我们证明在 85 kHz 下，原子磁力计可用于获取解剖图像。这是原子磁力计用于解剖 MRI 的首次演示。所展示的分辨率为 1.1 mm x 1.4 mm，采集时间约为 6 分钟，SNR 为 10。讨论了该方法的一些应用。我们讨论了几种提高灵敏度以达到 1 mm x 1 mm 分辨率的措施。由爱思唯尔公司出版
Ultra-low field (ULF) MRI is a promising method for inexpensive medical imaging with various additional advantages over conventional instruments such as low weight, low power, portability, absence of artifacts from metals, and high contrast. Anatomical ULF MRI has been successfully implemented with SQUIDs, but SQUIDs have the drawback of a cryogen requirement. Atomic magnetometers have sensitivity comparable to SQUIDs and can be in principle used for ULF MRI to replace SQUIDs. Unfortunately some problems exist due to the sensitivity of atomic magnetometers to a magnetic field and gradients. At low frequency, noise is also substantial and a shielded room is needed for improving sensitivity. In this paper, we show that at 85 kHz, the atomic magnetometer can be used to obtain anatomical images. This is the first demonstration of any use of atomic magnetometers for anatomical MRI. The demonstrated resolution is 1.1 mm x 1.4 mm in about 6 min of acquisition with SNR of 10. Some applications of the method are discussed. We discuss several measures to increase the sensitivity to reach a resolution 1 mm x 1 mm. Published by Elsevier Inc.