Age-related changes in the hemodynamics of the femoral head as evaluated by early phase of bone scintigraphy
Age-related changes in the hemodynamics of the femoral head as evaluated by early phase of bone scintigraphy
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DOI：
10.1007/bf02985588
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Kubo, T
中科院分区：
文献类型：
--
作者：
Hamaguchi, H;Fujioka, M;Kubo, T
目的：据报道，即使在正常条件下，与其他组织相比，股骨头也处于明显的低血状态，因此有必要了解其血流动力学以研究髋关节疾病的发病机制。众所周知，骨内血流动力学的各个方面，包括血流和血池，可以在放射性同位素给药后不久进行评价。在这项研究中，根据性别和年龄的股骨头血流动力学的变化进行了检查，通过调查在骨显像的早期阶段在组织中的放射性同位素的积累。研究方法：研究对象包括男性31例58个关节和女性41例75个关节，年龄15~87岁，平均67.9岁。在放射性同位素给药后5分钟和3小时获得骨密度成像15至20分钟。计算股骨头与骨干中的蓄积比（头-骨干比，HD比）。结果：15 - 20分钟后获得的HD比值范围为0.01 - 7.35（1.88 +/-0.91，平均值+/-SD）。HD比率随年龄增长而降低，年龄与HD比率之间存在显著的负相关性，相关系数为-0.27（p = 0.001）。男性的HD比率为0.01 - 3.57（1.66 +/-0.71），而女性为0.53 - 7.35（2.05 +/-1.01），男女之间的HD比率存在显著差异（p = 0.02）。在青少年至40多岁之间，男性和女性的HD比率存在显著差异（p = 0.03），而在其他年龄组中没有观察到显著差异。3小时后获得的HD比值范围为0.44 - 6.32（1.95 +/-0.79，平均值+/-SD），年龄与HD比值之间未观察到显著相关性，相关系数为-0.14。结论：股骨头血流量和血池随着年龄的增长而减少，女性股骨头血流量和血池的减少更为明显。老化引起的股骨头血流动力学恶化可能通过影响骨代谢而影响髋关节疾病的发生和进展。
Objective: The femoral head is reported to be in a markedly hypoemic state as compared with other tissues even under normal conditions, and it is therefore necessary to understand its hemodynamics to investigate the pathogenesis of hip disorders. It is known that aspects of intraosseous hemodynamics including blood flow and blood pool can be evaluated soon after radioisotope administration. In this study, hemodynamic changes in the femoral head according to gender and age were examined by investigating accumulation of radioisotope in the tissue during the early phase of bone scintigraphy. Methods: The subjects of this study consisted of 58 Joints of 3 1 men and 75 joints of 41 women, whose ages ranged from 15 to 87 years (average age: 67.9 years). Images of bone scintigraphy were obtained for 15 to 20 minutes at 5 minutes and at 3 hours after radioisotope administration. The ratio of accumulation in the femoral head to that in the diaphysis (head-to-diaphysis ratio, HD ratio) was calculated. Results: HD ratios obtained 15-20 minutes later ranged from 0.01 to 7.35 (1.88 +/- 0.91, mean +/- SD). HD ratios decreased with age, and a significant inverse correlation was observed between age and HD ratio, demonstrating a correlation coefficient of -0.27 (p = 0.001). The HD ratio among men was 0.01-3.57 (1.66 +/- 0.71), while that among women was 0.53-7.35 (2.05 +/- 1.01), and a significant difference was observed in HD ratio between men and women (p = 0.02). There was a significant difference in HD ratios between men and women in their teens to forties (p = 0.03), while no significant differences was observed in the other age groups. HD ratios obtained 3 hours later ranged from 0.44 to 6.32 (1.95 +/- 0.79, mean +/- SD), and no significant correlation was observed between age and HD ratio, demonstrating a correlation coefficient of -0.14. Conclusion: The present study demonstrated that blood flow and blood pool of the femoral head decrease with aging particularly in women. This hemodynamic deterioration of the femoral head caused by aging may have an effect on the onset and progression of hip disorders by influencing bone metabolism.