Medical burden in late-life bipolar and major depressive disorders
Medical burden in late-life bipolar and major depressive disorders
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DOI：
10.1097/jgp.0b013e318157c5b1
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发表时间：
2008-03-01
影响因子：
7.2
通讯作者：
Mulsant, Benoit H.
中科院分区：
文献类型：
--
作者：
Gildengers, Ariel G.;Whyte, Ellen M.;Mulsant, Benoit H.
背景：老年双相情感障碍患者的死亡率高于重度抑郁症患者。作者比较了老年双相情感障碍患者和重度抑郁症患者的医疗负担。研究方法：根据年龄、性别、种族和心境障碍疾病的终生持续时间，将54例60岁及以上的I型或II型双相情感障碍患者与108例非精神病性重度抑郁障碍患者进行1比2的等同。检查的变量包括：老年病累积疾病评定量表（CIRS-G）总分、体重指数（BMI）和CIRS-G子量表评分。结果如下：与重性抑郁症患者相比，双相情感障碍患者在CIRS-G总分和受累系统数量上的一般医疗合并症水平相似，但BMI较高。在控制多重比较后，双相情感障碍患者的CIRS-G内分泌/代谢和呼吸子量表评分较高。结论：尽管双相情感障碍老年患者和重度抑郁症患者的总体医疗负担似乎相当，但双相情感障碍患者的BMI较高，内分泌/代谢和呼吸系统疾病的负担更大。
Background: Elderly patients with bipolar disorder have been found to have higher mortality than those with major depressive disorder. The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder. Methods: Fifty-four patients with bipolar I or II disorder who were 60 years of age and older were equated 1-to-2 to 108 patients with nonpsychotic, major depressive disorder according to age, sex, race, and lifetime duration of mood disorder illness. Variables examined included the following: Cumulative Illness Rating Scale for Geriatrics (CIRS-G) total scores, body mass index (BMI), and CIRS-G subscale scores. Results: Compared with patients with major depressive disorder, patients with bipolar disorder had similar levels of general medical comorbidity on the CIRS-G total score and number of systems affected but higher BMI. After controlling for multiple comparisons, the endocrine/metabolic and respiratory subscale scores on the CIRS-G were higher for patients with bipolar disorder. Conclusion: Although overall medical burden appears comparable in elderly patients with bipolar and those with major depressive disorder, patients with bipolar disorder have higher BMI and greater burden of endocrine/metabolic and respiratory disease.