Effects of a urolith prevention diet on urine compositions of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats with calcium oxalate urolithiasis
Effects of a urolith prevention diet on urine compositions of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats with calcium oxalate urolithiasis
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DOI：
10.2460/ajvr.73.3.447
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发表时间：
2012-03-01
影响因子：
1
通讯作者：
Nakagawa, Yasushi
中科院分区：
文献类型：
--
作者：
Lulich, Jody P.;Osborne, Carl A.;Nakagawa, Yasushi
目的：评价饲粮预防草酸钙尿石的猫的尿中糖胺聚糖、Tamm-Horsfall糖蛋白和肾钙素的浓度。动物：10只患有草酸钙尿石症的猫。在之前根据平衡交叉设计进行的一项研究中，猫被连续喂食两种饲粮（每只猫在检测尿石之前食用的饲粮和一种配制的预防草酸钙尿石的饲粮）。每种饲粮饲喂8周。在每8周结束时，收集72小时尿液样本。在先前的研究中收集的尿液样本中，糖胺聚糖、Tamm-Horsfall糖蛋白和肾钙素的4种异构体的浓度在这里的研究中进行了测量。结果饲粮对大鼠尿中肾钙素和塔姆-马氏糖蛋白含量无显著影响。然而，在食用预防尿石饮食期间，尿中糖胺聚糖的浓度明显较高。结论及临床意义：饲粮预防尿石可增加尿中糖胺聚糖的浓度，糖胺聚糖是草酸钙晶体生长和聚集的糖蛋白抑制剂。（美国兽医杂志2012；73:447-451）
Objective-To evaluate urine concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats fed a diet formulated to prevent calcium oxalate uroliths.Animals-10 cats with calcium oxalate urolithiasis.Procedures-In a previous study conducted in accordance with a balanced crossover design, cats were sequentially fed 2 diets (the diet each cat was consuming prior to urolith detection and a diet formulated to prevent calcium oxalate uroliths). Each diet was fed for 8 weeks. At the end of each 8-week period, a 72-hour urine sample was collected. Concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and the 4 isoforms of nephrocalcin in urine samples collected during that previous study were measured in the study reported here.Results Diet had no effect on the quantity of Tamm-Horsfall glycoprotein and nephrocalcin in urine. However, the urine concentration of glycosaminoglycans was significantly higher during consumption of the urolith prevention diet.Conclusions and Clinical Relevance-Feeding a urolith prevention diet increased the urine concentration of glycosaminoglycans, which are glycoprotein inhibitors of growth and aggregation of calcium oxalate crystals. (Am J Vet Res 2012;73:447-451)