Circulating HCV-RNA, HCV genotype, and liver histology in asymptomatic individuals reactive for anti-HCV antibody and their follow-up study.
Circulating HCV-RNA, HCV genotype, and liver histology in asymptomatic individuals reactive for anti-HCV antibody and their follow-up study.
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对抗 HCV 抗体有反应的无症状个体的循环 HCV-RNA、HCV 基因型和肝脏组织学及其后续研究。
DOI：
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kei Kashima
中科院分区：
文献类型：
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作者：
T. Okanoue;K. Yasui;S. Sakamoto;M. Minami;Yasuyuki Nagao;Y. Itoh;K. Kagawa;Kei Kashima
本研究旨在澄清无症状、抗hcv抗体和肝脏检查正常的个体的病毒学状态、肝脏组织学和随访肝脏检查结果。本研究选取49例肝脏检查正常且第二代抗hcv抗体检测阳性的个体。评估丙型肝炎病毒血症患者的HCV基因型、循环HCV- rna量和肝脏组织学，并随访一年以上。聚合酶链反应（PCR）检测显示，49人中有36人患有丙型肝炎病毒血症。肝脏组织学：非特异性改变3例，慢性持续性肝炎（CPH） 25例，慢性活动性肝炎（CAH） 8例。24例CPH和CAH患者在随访12至32个月期间出现AST和/或ALT浓度升高（约30 IU/l）。循环HCV-RNA的数量从10(2)到10(7)拷贝/50微升血清。HCV基因型分布与症状性CAH基本相同。这些数据提示，对无症状丙型肝炎病毒血症患者进行组织学检查和随访检查是非常重要的，因为其中有一些干扰素治疗的候选者。在无症状的HCV携带者中，很少有人能保持健康。
The present study was aimed to clarify the virologic status, liver histologies, and the results of follow-up liver tests in symptom-free individuals with anti-HCV antibodies and normal liver tests. Forty-nine individuals with normal liver tests and positive second generation anti-HCV antibody assay were entered into this study. Cases with hepatitis C viremia were evaluated for HCV genotype, amount of circulating HCV-RNA, and liver histology and were followed-up for more than one year. Of the forty-nine individuals, 36 had hepatitis C viremia, indicated by polymerase chain reaction (PCR) assay. Liver histology was as follows: 3 had non-specific changes, 25 had chronic persistent hepatitis (CPH), and 8 had chronic active hepatitis (CAH). Twenty-four cases with CPH and CAH developed an elevated AST and/or ALT concentration (> 30 IU/l) between 12 and 32 months of follow-up. The amount of circulating HCV-RNA ranged from 10(2) to 10(7) copies/50 microliters serum. The distribution of HCV genotypes was nearly the same as that for symptomatic CAH. These data suggest that the histological examination and follow-up examination are very important for following symptom-free individuals with hepatitis C viremia because there are some candidates for interferon therapy among them. There are few individuals who will remain healthy among asymptomatic HCV carriers.
DOI：
10.1073/pnas.87.7.2725
发表时间：
1990-04-01
影响因子：
11.1
作者：
GILLILAND, G;PERRIN, S;BUNN, HF
通讯作者：
BUNN, HF