HEMORRHAGIC-FEVER WITH RENAL SYNDROME - CLINICAL ASPECTS
HEMORRHAGIC-FEVER WITH RENAL SYNDROME - CLINICAL ASPECTS
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DOI：
10.1007/bf00866316
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发表时间：
1992-03-01
影响因子：
3
通讯作者：
KO, KW
中科院分区：
文献类型：
--
作者：
KO, KW
根据临床和病理特点，肾综合征出血热的典型病例可分为五个阶段：（1）发热期。(2)（3）少尿期。(4)利尿期;（5）恢复期。主要表现为发热、腰腹疼痛。面色潮红、虚脱、蛋白尿、紫癜、出血、急性肾功能衰竭。选择性右耳出血、肾髓质明显充血出血和脑垂体前叶坏死是三个突出的病理改变。临床严重程度取决于病原体，即汉滩病毒、首尔病毒和欧洲型。肾综合征出血热的特异性血清学诊断是通过显示抗汉滩病毒和相关病毒的特异性免疫荧光抗体滴度升高来进行的。管理是支持性的，基于对疾病的病理生理学的理解。
Based on clinical and pathological features a typical case of haemorrhagic fever with renal syndrome passes through five phases: (1) febrile phase. (2) hypotensive phase, (3) oliguric phase. (4) diuretic phase and (5) convalescent phase. The major manifestations are fever, pain in the back and abdomen. flushed face, prostration, proteinuria, purpura and haemorrhage and acute renal failure. Selective right auricular haemorrhage, marked congestion and haemorrhage in the renal medulla and necrosis of the anterior lobe of the pituitary gland are the three prominent pathological findings. The clinical severity depends upon the causative agents, namely Hantaan virus, Seoul virus and the European form in that order. Specific serological diagnosis of haemorrhagic fever with renal syndrome is made by demonstrating a rise in titre of specific immunofluorescent antibody against Hantaan and related viruses. The management is supportive, based on an understanding of the pathophysiology of the disease.