A gamma-melanocyte stimulating hormone-like peptide causes reflex natriuresis after acute unilateral nephrectomy.
A gamma-melanocyte stimulating hormone-like peptide causes reflex natriuresis after acute unilateral nephrectomy.
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γ-黑素细胞刺激激素样肽在急性单侧肾切除术后引起反射性排尿钠。
DOI：
10.1161/01.hyp.10.6.619
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Humphreys,MH
中科院分区：
文献类型：
--
作者：
Lin,SY;Chaves,C;Wiedemann,E;Humphreys,MH
先前的研究已经表明，急性单侧肾切除术通过需要完整脑下垂体的反射途径刺激剩余肾脏的钠（UNaV）和钾（UKV）排泄，并且尿钠排泄伴随着源自促肾上腺皮质激素β-内啡肽前体分子阿黑皮素原的一种或多种肽的血浆浓度的增加。我们测试的假设，γ-黑素细胞刺激激素（γ-MSH）是这样一种肽参与肾切除术后尿钠排泄。在6只接受假肾切除术的大鼠中，UNaV或UKV没有发生变化，假手术后2小时血浆免疫反应性γ-MSH样物质为40 +/- 18（SD）fmol/ml。在10只接受急性单侧肾切除术的大鼠中，来自剩余肾脏的UNaV和UKV显著增加，免疫反应性γ-MSH为81 +/- 36 fmol/ml（p <0.02）。在个别研究中，肾切除术后UNaV的增加与肾切除术后免疫反应性γ-MSH的浓度相关（r = 0.75，p <0.001）。在17只注射对照兔血清或球蛋白的大鼠中，单侧肾切除导致UNaV和UKV的预期增加。在23只大鼠中，注射抗γ-MSH免疫的兔血清或球蛋白后，肾切除术后未发生尿钠排泄，尿钾排泄减弱。在水缺乏，盐皮质激素治疗的大鼠，静脉输注合成γ-MSH导致尿钠排泄和尿钾排泄，菊粉清除率没有变化;预处理兔抗γ-MSH抗血清阻断这种效果的肽输注。（250字处删节）
Previous studies have shown that acute unilateral nephrectomy stimulates sodium (UNaV) and potassium (UKV) excretion by the remaining kidney through reflex pathways requiring an intact pituitary gland, and the natriuresis is accompanied by an increase in the plasma concentration of a peptide or peptides derived from the adrenocorticotropic hormone-beta-endorphin precursor molecule pro-opiomelanocortin. We tested the hypothesis that gamma-melanocyte stimulating hormone (gamma-MSH) was such a peptide involved in the postnephrectomy natriuresis. In six rats undergoing sham nephrectomy, no change in UNaV or UKV occurred and plasma immunoreactive gamma-MSH-like material was 40 +/- 18 (SD) fmol/ml 2 hours after the sham procedure. In 10 rats undergoing acute unilateral nephrectomy, UNaV and UKV from the remaining kidney increased significantly, and immunoreactive gamma-MSH was 81 +/- 36 fmol/ml (p less than 0.02). In individual studies, the increase in UNaV after nephrectomy correlated with the postnephrectomy concentration of immunoreactive gamma-MSH (r = 0.75, p less than 0.001). In 17 rats injected with serum or globulin from control rabbits, unilateral nephrectomy led to the expected increases in UNaV and UKV. In 23 rats injected with serum or globulin from rabbits immunized against gamma-MSH, no postnephrectomy natriuresis occurred and the kaliuresis was blunted. In hydropenic, mineralocorticoid-treated rats, intravenous infusion of synthetic gamma-MSH led to natriuresis and kaliuresis with no change in inulin clearance; pretreatment with rabbit anti-gamma-MSH antiserum blocked this effect of peptide infusion.(ABSTRACT TRUNCATED AT 250 WORDS)